{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:01:38Z","timestamp":1771304498009,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000329","name":"Novo Nordisk UK Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007398","name":"Strategiske Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007398","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Intestinal bacterial translocation is involved in activation of liver macrophages in cirrhotic patients. Macrophages play a key role in liver inflammation and are involved in the pathogenesis of cirrhosis and complications. Bacterial translocation may be determined by presence of bacterial <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> and macrophage activation, by the soluble mannose receptor. We hypothesize that the soluble mannose receptor is released from hepatic macrophages in cirrhosis and associated with bacterial <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>, portal pressure and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated 28 cirrhotic patients set for transjugular intrahepatic portosystemic shunt insertion as a result of refractory ascites (n=17), acute (n=3), or recurrent variceal bleeding (n=8). We analysed plasma from the portal and hepatic veins for bacterial <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> and soluble mannose receptor with <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content> and ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median soluble mannose receptor level was elevated in the hepatic vein compared with the portal vein (0.57(interquartile range 0.31) vs 0.55(0.40) mg\/L, <jats:italic>P<\/jats:italic>=.005). The soluble mannose receptor levels were similar in bacterial <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\u2010positive and \u2010negative patients. The soluble mannose receptor level in the portal and hepatic veins correlated with the portal pressure prior to transjugular intrahepatic portosystemic shunt insertion (<jats:italic>r<\/jats:italic>=.52, <jats:italic>P<\/jats:italic>&lt;.008, both) and the levels correlated with Child\u2010Pugh score (<jats:italic>r<\/jats:italic>=.63 and <jats:italic>r<\/jats:italic>=.56, <jats:italic>P<\/jats:italic>&lt;.004, both). We observed higher soluble mannose receptor levels in patients with acute variceal bleeding compared to other indications (<jats:italic>P<\/jats:italic>&lt;.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed hepatic soluble mannose receptor excretion with a higher level in the hepatic than the portal vein, though with no associations to bacterial <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>. We observed associations between soluble mannose receptor levels and portal pressure and higher levels in patients with acute variceal bleeding indicating the soluble mannose receptor as a marker of complications of cirrhosis, but not bacterial translocation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13262","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T18:54:41Z","timestamp":1476298481000},"page":"569-575","source":"Crossref","is-referenced-by-count":11,"title":["The soluble mannose receptor is released from the liver in cirrhotic patients, but is not associated with bacterial translocation"],"prefix":"10.1111","volume":"37","author":[{"given":"Tea L.","family":"Laursen","sequence":"first","affiliation":[{"name":"Department of Hepatology &amp; Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidsel","family":"R\u00f8dgaard\u2010Hansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger J.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hvidovre University Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stine","family":"Karlsen","sequence":"additional","affiliation":[{"name":"Department of Hepatology &amp; Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis T.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Radiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Frevert","sequence":"additional","affiliation":[{"name":"Department of Radiology Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens O.","family":"Clemmesen","sequence":"additional","affiliation":[{"name":"Department of Hepatology Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Centre of Functional Imaging and Research Hvidovre University Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen S.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Mycoplasma Laboratory Microbiology and Infection Control Statens Serum Institut Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flemming","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hvidovre University Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Gr\u00f8nb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Hepatology &amp; 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