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These metabolic complications of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> have been shown to accelerate the progression of fibrosis to cirrhosis and increase the risk of hepatocellular carcinoma. The metabolic syndrome is a common disorder that also includes <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>, T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> and hepatic steatosis. Approximately 20%\u201030% of patients with chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> also have co\u2010existent metabolic syndrome. The cause of steatosis in patients with the features of both the metabolic syndrome and chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> is sometime difficult to determine. Patients with metabolic syndrome and chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> are also at risk of developing renal, cardiovascular and cerebrovascular disease. Recent data suggest that <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> is an independent risk factor for renal, coronary and cerebral vascular disease, and may increase mortality associated with these disorders. The treatment of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> can now result in a sustained virological response and cure nearly all patients with chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. The eradication of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> reduces the risk of developing <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> and T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>, improves <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> and 2<jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content>, reduces the risk of developing chronic kidney disease, end\u2010stage renal disease, acute cardiac syndrome and stroke in patients with 2<jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content>. Thus, treatment of chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> can provide a significant public health benefit, but only if all patients with chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> are identified and universally treated.<\/jats:p>","DOI":"10.1111\/liv.13282","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T04:15:37Z","timestamp":1484280937000},"page":"13-18","source":"Crossref","is-referenced-by-count":23,"title":["Impact of hepatitis C virus therapy on metabolism and public health"],"prefix":"10.1111","volume":"37","author":[{"given":"Mitchell L.","family":"Shiffman","sequence":"first","affiliation":[{"name":"Liver Institute of Virginia Bon Secours Health System  Richmond and Newport News VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadege T.","family":"Gunn","sequence":"additional","affiliation":[{"name":"Liver Institute of Virginia Bon Secours 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