{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:46:26Z","timestamp":1791773186973,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T00:00:00Z","timestamp":1479513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Direct\u2010acting oral anticoagulants (<jats:styled-content style=\"fixed-case\">DOAC<\/jats:styled-content>s) are used in patients with splanchnic vein thrombosis (<jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content>) and cirrhosis, but evidence for safety and efficacy in this setting is limited. Our aim was to identify indications and reasons for starting or switching to <jats:styled-content style=\"fixed-case\">DOAC<\/jats:styled-content>s and to report adverse effects, complications and short\u2010term outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data collection including demographic information, laboratory values, treatment and complications through the Vascular Liver Disease Interest Group Consortium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five centres (90%) of the consortium completed the initial <jats:styled-content style=\"fixed-case\">eCRF<\/jats:styled-content>. We report here a series of 94 patients from 17 centres. Thirty\u2010six patients (38%) had cirrhosis. Child\u2010Pugh score was 6 (range 5\u20108), and <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> score 10.2 (range 6\u201019). Indications for anticoagulation were splanchnic vein thrombosis (75%), deep vein thrombosis (5%), atrial fibrillation (14%) and others (6%). <jats:styled-content style=\"fixed-case\">DOAC<\/jats:styled-content>s used were rivaroxaban (83%), dabigatran (11%) and apixaban (6%). Patients were followed up for a median duration of 15\u00a0months (cirrhotic) and 26.5\u00a0months (non\u2010cirrhotic). Adverse events occurred in 17% of patients and included one case of recurrent portal vein thrombosis and five cases of bleeding. Treatment with <jats:styled-content style=\"fixed-case\">DOAC<\/jats:styled-content>s was stopped in three cases. The major reasons for choosing <jats:styled-content style=\"fixed-case\">DOAC<\/jats:styled-content>s were no need for monitoring or inadequacy of <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content> to guide anticoagulation in cirrhotic patients. Renal and liver function did not change during treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A consistent number of patients with <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content> and\/or cirrhosis are currently treated with <jats:styled-content style=\"fixed-case\">DOAC<\/jats:styled-content>s, which seem to be effective and safe. These data provide a basis for performing randomized clinical trials of <jats:styled-content style=\"fixed-case\">DOAC<\/jats:styled-content>s vs. low molecular weight heparin or vitamin K antagonists.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13285","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T07:52:57Z","timestamp":1477381977000},"page":"694-699","source":"Crossref","is-referenced-by-count":202,"title":["Antithrombotic treatment with direct\u2010acting oral anticoagulants in patients with splanchnic vein thrombosis and cirrhosis"],"prefix":"10.1111","volume":"37","author":[{"given":"Andrea","family":"De Gottardi","sequence":"first","affiliation":[{"name":"Hepatology Department of Clinical Research and Clinic of Visceral Surgery and Medicine Inselspital University of Berne  Berne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonel","family":"Trebicka","sequence":"additional","affiliation":[{"name":"University Hospital  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Klinger","sequence":"additional","affiliation":[{"name":"Klinikum Ludwigsburg  Ludwigsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Plessier","sequence":"additional","affiliation":[{"name":"DHU Unit H\u00f4pital Beaujon  Clichy\u2010la\u2010Garenne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Seijo","sequence":"additional","affiliation":[{"name":"King's College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Terziroli","sequence":"additional","affiliation":[{"name":"Epatocentro Ticino  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Magenta","sequence":"additional","affiliation":[{"name":"Epatocentro Ticino  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Semela","sequence":"additional","affiliation":[{"name":"Kantonsspital St. Gallen  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Buscarini","sequence":"additional","affiliation":[{"name":"Maggiore Hospital  Crema Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Langlet","sequence":"additional","affiliation":[{"name":"CHIREC  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"G\u00f6rtzen","sequence":"additional","affiliation":[{"name":"University Hospital  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Puente","sequence":"additional","affiliation":[{"name":"HUMV and Investigation Institute Marques de Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"M\u00fcllhaupt","sequence":"additional","affiliation":[{"name":"University Hospital  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Navascu\u00e8s","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe","family":"Nery","sequence":"additional","affiliation":[{"name":"Hospital Santo Antonio  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Deltenre","sequence":"additional","affiliation":[{"name":"CHUV  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Turon","sequence":"additional","affiliation":[{"name":"Hospital Clinic IDIBAPS and CIBERehd  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius","family":"Engelmann","sequence":"additional","affiliation":[{"name":"University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupen","family":"Arya","sequence":"additional","affiliation":[{"name":"King's College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Caca","sequence":"additional","affiliation":[{"name":"Klinikum Ludwigsburg  Ludwigsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Peck\u2010Radosavljevic","sequence":"additional","affiliation":[{"name":"Medical University  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank W. 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