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However, hepatitis B\u2010related morbidity and mortality remain a major global health threat. This is partly due to the escalating costs and the decrease in compliance related to the need for prolonged therapy for most patients who cannot be \u201ccured\u201d. New biomarkers such as quantitative hepatitis B surface antigen might help to determine if hepatitis B e antigen negative patients can be taken off nucleos(t)ide analogues. On the other hand, novel compounds that target the viral life cycle or modulate host immune response are in the pipeline. In the next few years, one should expect breakthrough advancement to be made leading to a \u201ccure\u201d for patients with chronic hepatitis B infection by inducing hepatitis surface antigen loss with or without the development of the hepatitis B surface antibody. In addition, attention and necessary actions should also be taken in patients with hepatitis B infection who are being treated with immunosuppressive therapy and direct anti\u2010viral (<jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s) agents for hepatitis C infection to prevent hepatitis from hepatitis B reactivation.<\/jats:p>","DOI":"10.1111\/liv.13309","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T04:15:37Z","timestamp":1484280937000},"page":"59-66","source":"Crossref","is-referenced-by-count":29,"title":["Treatment of chronic hepatitis B infection\u20102017"],"prefix":"10.1111","volume":"37","author":[{"given":"Guo\u2010Feng","family":"Chen","sequence":"first","affiliation":[{"name":"Beijing 302\u2010Hong Kong Humanity and Health Hepatitis C Diagnosis and Treatment Center  Beijing China"},{"name":"Second Liver Cirrhosis Diagnosis and Treatment Center 302 Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing 302\u2010Hong Kong Humanity and Health Hepatitis C Diagnosis and Treatment Center  Beijing China"},{"name":"Division of Gastroenterology and Hepatology Humanity and Health Medical Centre  Hong Kong SAR China"},{"name":"State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of Viral Hepatitis Research Department of Infectious Diseases Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Lau","sequence":"additional","affiliation":[{"name":"Beijing 302\u2010Hong Kong Humanity and Health Hepatitis C Diagnosis and Treatment Center  Beijing China"},{"name":"Division of Gastroenterology and Hepatology Humanity and Health Medical Centre  Hong Kong SAR China"},{"name":"Institute of Translational Hepatology 302 Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.02.010"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-007-9006-5"},{"key":"e_1_2_11_4_1","unstructured":"World Health Organization.Guidelines for the prevention care and treatment of persons with chronic hepatitis B infection. 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