{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:01:58Z","timestamp":1792065718893,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,12,6]],"date-time":"2016-12-06T00:00:00Z","timestamp":1480982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science KAKENHI","doi-asserted-by":"crossref","award":["26460996"],"award-info":[{"award-number":["26460996"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>Primary biliary cholangitis (PBC<\/jats:styled-content>) is an autoimmune liver disease characterized by portal inflammation and immune\u2010mediated destruction of intrahepatic bile ducts that often leads to liver decompensation and liver failure. Although the biochemical response to ursodeoxycholic acid (UDCA<\/jats:styled-content>) can predict disease outcome in PBC<\/jats:styled-content>, few biomarkers have been identified as prognostic tools applicable prior to UDCA<\/jats:styled-content> treatment. We therefore sought to identify such indicators of long\u2010term outcome in PBC<\/jats:styled-content> in the Japanese population.<\/jats:p><\/jats:sec>Methods<\/jats:title>The prebiopsy serum samples and subsequent clinical data of 136 patients with PBC<\/jats:styled-content> treated with UDCA<\/jats:styled-content> were analysed over a median follow\u2010up period of 8.8\u00a0years. Serum levels of biomarkers related to microbial translocation (sCD<\/jats:styled-content>14, EndoCA<\/jats:styled-content>b and I\u2010FABP<\/jats:styled-content>) were measured along with those of 33 cytokines and chemokines and additional auto\u2010antibodies. Associations between the tested parameters and the clinical outcomes of liver decompensation and liver\u2010related death\/liver transplantation were evaluated using the Cox proportional hazards model with stepwise methods and Kaplan\u2010Meier analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>Elevated levels of serum IL<\/jats:styled-content>\u20108, and sCD<\/jats:styled-content>14 before UDCA<\/jats:styled-content> therapy were significantly associated with both liver decompensation and liver\u2010related death\/liver transplantation. In multivariate analyses, IL<\/jats:styled-content>\u20108\u226546.5\u00a0pg\/mL<\/jats:styled-content> or sCD<\/jats:styled-content>14\u22652.0\u00a0\u03bcg\/mL<\/jats:styled-content> at enrolment demonstrated the same results. Kaplan\u2010Meier analysis also revealed IL<\/jats:styled-content>\u20108 and sCD<\/jats:styled-content>14 to be significantly associated with a poor outcome. sCD<\/jats:styled-content>14 was significantly correlated with IL<\/jats:styled-content>\u20108. EndoCA<\/jats:styled-content>b and I\u2010FABP<\/jats:styled-content> were not related to disease outcome.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Serum IL<\/jats:styled-content>\u20108 and sCD<\/jats:styled-content>14 levels before UDCA<\/jats:styled-content> therapy represent noninvasive surrogate markers of prognosis in patients with PBC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13316","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T13:32:44Z","timestamp":1479389564000},"page":"897-905","source":"Crossref","is-referenced-by-count":24,"title":["Association between serum soluble CD<\/scp>14 and IL<\/scp>\u20108 levels and clinical outcome in primary biliary cholangitis"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-919X","authenticated-orcid":false,"given":"Takeji","family":"Umemura","sequence":"first","affiliation":[{"name":"Division of Hepatology and Gastroenterology 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