{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:52:51Z","timestamp":1761630771500,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T00:00:00Z","timestamp":1482710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>Hepatitis C virus (HCV<\/jats:styled-content>) re\u2010infection following liver transplant (LT<\/jats:styled-content>) is associated with reduced graft and patient survival. Before transplant, Sofosbuvir\/Ribavirin (SOF<\/jats:styled-content>\/R) treatment prevents recurrent HCV<\/jats:styled-content> in 96% of those patients achieving viral suppression for at least 4\u00a0weeks before transplant. We evaluated whether a bridging SOF<\/jats:styled-content>\u2010regimen from pre\u2010 to post\u2010transplant is safe and effective to prevent HCV<\/jats:styled-content> recurrence in those patients with less than 4\u00a0weeks of HCV<\/jats:styled-content>\u2010RNA<\/jats:styled-content> undetectability at the time of transplant.<\/jats:p><\/jats:sec>Methods<\/jats:title>From July 2014 SOF<\/jats:styled-content>\/R was given in 233 waitlisted HCV<\/jats:styled-content> cirrhotics with\/without hepatocellular carcinoma (HCC<\/jats:styled-content>) within an Italian Compassionate Program. One hundred patients were transplanted and 31 patients (31%) treated with SOF<\/jats:styled-content>\/R bridging therapy were studied.<\/jats:p><\/jats:sec>Results<\/jats:title>Liver transplant indication in bridge subgroup was HCC<\/jats:styled-content> in 22 and decompensated cirrhosis in 9. HCV<\/jats:styled-content>\u2010genotype was 1\/4 in 18 patients. SOF<\/jats:styled-content> 400\u00a0mg\/day and R (median dosage 800\u00a0mg\/day) were given for a median of 35\u00a0days before LT<\/jats:styled-content>. At transplant time, 19 patients were still HCV<\/jats:styled-content>\u2010RNA<\/jats:styled-content> positive (median HCV<\/jats:styled-content>\u2010RNA<\/jats:styled-content> 58\u00a0IU\/mL). One recipient had a virological breakthrough at week 4 post\u2010transplant; one died, on treatment, 1\u2010month post\u2010transplant for sepsis and 29\/31 achieved a 12\u2010week sustained virological response (94%). Acute cellular rejection occurred in three recipients. On September 2016, 30 recipients (97%) were alive with a median follow\u2010up of 18\u00a0months (range 13\u201025).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In patients with suboptimal virological response at LT<\/jats:styled-content>, a bridging SOF<\/jats:styled-content>\/R regimen helps avoiding post\u2010transplant graft reinfection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13322","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T14:02:43Z","timestamp":1479564163000},"page":"678-683","source":"Crossref","is-referenced-by-count":10,"title":["Prevention of hepatitis C recurrence by bridging sofosbuvir\/ribavirin from pre\u2010 to post\u2010liver transplant: a real\u2010life strategy"],"prefix":"10.1111","volume":"37","author":[{"given":"Maria Francesca","family":"Donato","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Morelli","sequence":"additional","affiliation":[{"name":"U.O. Medicina Interna e delle Insufficienze d'Organo\u2014Azienda Ospedaliera\u2010Universitaria Policlinico S. Orsola\u2010Malpighi di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8340-8885","authenticated-orcid":false,"given":"Renato","family":"Romagnoli","sequence":"additional","affiliation":[{"name":"Liver Transplantation Center General Surgery Unit 2U AOU Citt\u00e0 della Salute e della Scienza di Torino University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Invernizzi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Mazzarelli","sequence":"additional","affiliation":[{"name":"Hepatology Unit and Liver Transplantation Surgery Niguarda Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Maria","family":"Iemmolo","sequence":"additional","affiliation":[{"name":"Liver and Multivisceral Transplant Center Azienda Ospedaliero\u2010Universitaria di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzia","family":"Montalbano","sequence":"additional","affiliation":[{"name":"Infectious Diseases and General Surgery National Institute for Infectious Diseases Spallanzani Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Lenci","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit and Experimental Medicine and Surgery University of Tor Vergata Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherrie","family":"Bhoori","sequence":"additional","affiliation":[{"name":"Surgery and Liver Transplantation Unit IRCCS National Institute of Cancer Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Pieri","sequence":"additional","affiliation":[{"name":"Division of Hepatology IRCCS AO San Martino IST Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Berardi","sequence":"additional","affiliation":[{"name":"U.O. Medicina Interna e delle Insufficienze d'Organo\u2014Azienda Ospedaliera\u2010Universitaria Policlinico S. Orsola\u2010Malpighi di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Caraceni","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences S. 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