{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:14:41Z","timestamp":1780377281272,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1064533"],"award-info":[{"award-number":["APP1064533"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1061332"],"award-info":[{"award-number":["APP1061332"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001077","name":"Royal Brisbane and Women's Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001056","name":"Gallipoli Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Ferritin is purported to have proinflammatory and profibrogenic effects on hepatic stellate cells. Thus, rather than acting as a passive indicator of hepatic iron concentration (<jats:styled-content style=\"fixed-case\">HIC<\/jats:styled-content>) in haemochromatosis, ferritin may directly influence fibrosis. This study evaluated whether serum ferritin is a better predictor of hepatic fibrosis compared to variables previously associated with increased fibrosis risk in haemochromatosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified 291 C282Y <jats:italic><jats:styled-content style=\"fixed-case\">HFE<\/jats:styled-content>\u2010<\/jats:italic>homozygous patients who had undergone liver biopsy for histological fibrosis staging and measurement of <jats:styled-content style=\"fixed-case\">HIC<\/jats:styled-content>. Ordinal logistic regression determined the best model for fibrosis stage <jats:italic>not<\/jats:italic> including serum ferritin. Then, serum ferritin was introduced into this model to assess whether the predictive power of the model was significantly increased and to evaluate the effect on other predictors of fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ordinal logistic regression analyses without serum ferritin demonstrated that log <jats:styled-content style=\"fixed-case\">HIC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.89; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.001), male gender (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.93; <jats:italic>P\u00a0<\/jats:italic>=\u00a0.005), alcohol consumption (g\/day) (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.01; <jats:italic>P\u00a0<\/jats:italic>=\u00a0.004), steatosis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.86; <jats:italic>P\u00a0<\/jats:italic>=\u00a0.01), arthritis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.46; <jats:italic>P\u00a0<\/jats:italic>=\u00a0.01) predicted increasing fibrosis stage (<jats:italic>n<\/jats:italic>=217). Addition of serum ferritin in multivariate analysis substantially improved the predictive power of the model (\u03c7<jats:sup>2\u00a0<\/jats:sup>=\u00a037.15; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.01) and was highly predictive of fibrosis stage (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.44; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.001). Inclusion of serum ferritin in this model rendered the effects of <jats:styled-content style=\"fixed-case\">HIC<\/jats:styled-content>, gender, alcohol and steatosis to non\u2010significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In haemochromatosis, serum ferritin is a better predictor of fibrosis stage than <jats:styled-content style=\"fixed-case\">HIC<\/jats:styled-content>, gender, steatosis and alcohol. These data support a hypothesis that ferritin may play a role in fibrosis rather than simply acting as a passive indicator of iron storage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13395","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T18:48:59Z","timestamp":1487875739000},"page":"1382-1388","source":"Crossref","is-referenced-by-count":26,"title":["Serum ferritin concentration predicts hepatic fibrosis better than hepatic iron concentration in human <i><scp>HFE<\/scp>\u2010<\/i>Haemochromatosis"],"prefix":"10.1111","volume":"37","author":[{"given":"Marnie J.","family":"Wood","sequence":"first","affiliation":[{"name":"Hepatic Fibrosis Group QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"},{"name":"Department of Gastroenterology and Hepatology Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"},{"name":"School of Medicine The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell H. G.","family":"Crawford","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Greenslopes Hospital The Gallipoli Medical Research Foundation  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8921-9265","authenticated-orcid":false,"given":"Leesa F.","family":"Wockner","sequence":"additional","affiliation":[{"name":"Biostatistics Group QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrie W.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"},{"name":"School of Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Centre for the Advancement of Clinical Research Royal Brisbane and Women's Hospital and the University of Queensland Centre for Clinical Research  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-6201","authenticated-orcid":false,"given":"Grant A.","family":"Ramm","sequence":"additional","affiliation":[{"name":"Hepatic Fibrosis Group QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"},{"name":"School of Medicine The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0896-399"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104742"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073286"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80424-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.3.294"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25720"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.30992"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22716"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31274-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23537"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24706"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26706"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1309\/X4UH5Q68Q4J3GDNV"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12327"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.35343"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22650"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12762"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03472.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117353"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00444-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90331-R"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.00969.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27662"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i5.596"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1344-z"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11901-010-0049-z"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.13395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.13395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:58:35Z","timestamp":1695553115000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.13395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,17]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/liv.13395"],"URL":"https:\/\/doi.org\/10.1111\/liv.13395","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,17]]}}}