{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:17:03Z","timestamp":1762507023934,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Familial aggregation of metabolic traits with fatty liver disease is well documented. However, there is scarcity of data regarding such association with non\u2010alcoholic steatohepatitis (<jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content>)\u2010related cirrhosis. This study was aimed to explore the association of family history of metabolic traits with severity of cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross\u2010sectional study, all consecutive patients with <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content>\u2010related cirrhosis presenting to our tertiary care centre were included. Family history, personal history, demographic characteristics, medical history, anthropometric measurements and laboratory data were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1133 cirrhotics (68.1% males, age 51.4\u00b110.9\u00a0years); 779 (68.8%) had family history for metabolic traits. These patients had lower age at diagnosis (45.4\u00b110.6 vs 49.6\u00b111.2\u00a0years), higher Child\u2013Turcotte\u2013Pugh (<jats:styled-content style=\"fixed-case\">CTP<\/jats:styled-content>) score (7.8\u00b11.9 vs 6.6\u00b11.5), higher model for end stage liver disease (<jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>) score (12.9\u00b16.1 vs 10.9\u00b14.1) and more incidence of decompensation in the form of ascites (46.3% vs 25.7%), jaundice (12.1% vs 6.2%) and hepatic encephalopathy (26.1% vs 11.0%). Patients with family and personal history of metabolic traits, had an increased risk of an early diagnosis of cirrhosis at&lt;45\u00a0years of age (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3.1, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.1\u20104.4), <jats:styled-content style=\"fixed-case\">CTP<\/jats:styled-content>\u226510 (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 4.6, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.3\u20109.1), <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>&gt;15 (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 6.6, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.8\u201011.5) with \u22651 features of decompensation (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 4.2, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.9\u20106.1). Family history of diabetes alone, also had higher risk of cirrhosis with <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>&gt;15 (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 4.3, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.4\u20105.3, <jats:italic>P<\/jats:italic>&lt;.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Family and personal history of metabolic traits are associated with early age at diagnosis of cirrhosis with more severity and decompensation and so, has a prognostic importance in <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content>\u2010related cirrhotics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13396","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T18:54:14Z","timestamp":1487876054000},"page":"1397-1404","source":"Crossref","is-referenced-by-count":18,"title":["Impact of family history of metabolic traits on severity of non\u2010alcoholic steatohepatitis related cirrhosis: A cross\u2010sectional study"],"prefix":"10.1111","volume":"37","author":[{"given":"Ajeet S.","family":"Bhadoria","sequence":"first","affiliation":[{"name":"Department of Clinical Research Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandan K.","family":"Kedarisetty","sequence":"additional","affiliation":[{"name":"Department of Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chhagan","family":"Bihari","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guresh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Institute of Liver and Biliary Sciences  New Delhi 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