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We sought to evaluate the relationship between <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> components and the risk of severe hepatic fibrosis in <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> patients discriminated by age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We considered 863 consecutive patients with biopsy\u2010proven <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>, who had been fully evaluated for components of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate logistic regression analysis showed that F3\u2010F4 was associated with visceral obesity, <jats:styled-content style=\"fixed-case\">IFG<\/jats:styled-content>\/diabetes, and low high\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>) cholesterol, but not triglycerides &gt;150 or arterial hypertension. A significant interaction was found between age and visceral obesity (<jats:italic>P<\/jats:italic>=.04). By stratifying patients for age, we confirmed the interaction between inclusion in the third age tertile (&gt;54\u00a0years) and visceral obesity (<jats:italic>P<\/jats:italic>=.04). In the lower (&lt;41\u00a0years) and middle (41\u201054\u00a0years) age tertiles, the risk for F3\u2010F4 fibrosis was mostly driven by visceral obesity and <jats:styled-content style=\"fixed-case\">IFG<\/jats:styled-content>\/diabetes. This risk was higher in those with all three metabolic risk factors. Finally, among patients in the higher age tertile (&gt;54\u00a0years), obesity did not affect the severity of fibrosis, and the risk of severe fibrosis was higher in those with low <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IFG<\/jats:styled-content>\/diabetes with\/without visceral obesity (52%\u201054%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among patients with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>, the metabolic profiles associated with risk for severe fibrosis varied among age groups. Low <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>, obesity and <jats:styled-content style=\"fixed-case\">IFG<\/jats:styled-content>\/diabetes were prevalent among patients in the lower and middle age tertiles. <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IFG<\/jats:styled-content>\/diabetes but not visceral obesity were prevalent among those in the highest age tertile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13397","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T20:27:07Z","timestamp":1487968027000},"page":"1389-1396","source":"Crossref","is-referenced-by-count":51,"title":["Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age\u2010dependent risk profiling 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