{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:05:23Z","timestamp":1769814323468,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>The definition of new biomarkers of hepatocellular carcinoma (HCC<\/jats:styled-content>) risk, especially in high\u2010risk HBV<\/jats:styled-content>\/HCV<\/jats:styled-content>\u2010positive population, is urgently needed to improve HCC<\/jats:styled-content> clinical management. This study focused on variants of UDP<\/jats:styled-content>\u2010glucuronosyltransferase 1A (UGT<\/jats:styled-content>1A) enzymes that catalyse the reaction of glucuronidation, one of the most important chemical defence pathway of the body. The aim of this study was to elucidate the contribution of UGT<\/jats:styled-content>1A<\/jats:italic> polymorphisms in predicting HCC<\/jats:styled-content> susceptibility in Caucasians.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this retrospective case\u2010control analysis, 192 HCC<\/jats:styled-content> liver transplanted patients represent the study group. Two age\/sex\u2010matched groups were used as control, one composed of 167 HBV<\/jats:styled-content>\u2010 and\/or HCV<\/jats:styled-content>\u2010infected individuals, and the other of 192 healthy subjects. All the cases were characterized for a panel of UGT<\/jats:styled-content>1A1<\/jats:italic>, UGT<\/jats:styled-content>1A7<\/jats:italic> and UGT<\/jats:styled-content>1A9<\/jats:italic> variants. The study end\u2010point was the association between UGT<\/jats:styled-content>1A<\/jats:italic> markers and HCC<\/jats:styled-content> onset.<\/jats:p><\/jats:sec>Results<\/jats:title>UGT<\/jats:styled-content>1A7<\/jats:italic>*3 allele emerged as a protective marker for HCC<\/jats:styled-content> development among both high\u2010risk HBV<\/jats:styled-content>\/HCV<\/jats:styled-content>\u2010positive patients (OR<\/jats:styled-content>=0.64, P<\/jats:italic>=.0026), and healthy subjects (OR<\/jats:styled-content>=0.47, P<\/jats:italic>=.0051). UGT<\/jats:styled-content>1A1<\/jats:italic>*28 (OR<\/jats:styled-content>=0.61, P<\/jats:italic>=.0013) and UGT<\/jats:styled-content>1A9<\/jats:italic>*22 (OR<\/jats:styled-content>=2.18, P<\/jats:italic>=.0003) alleles were also associated to HCC<\/jats:styled-content> occurrence, especially among healthy subjects. UGT<\/jats:styled-content>1A<\/jats:italic> haplotype, summarizing the UGT<\/jats:styled-content>1A genetic alterations, confirmed the protective role against HCC<\/jats:styled-content> development emerged for low\u2010activity alleles. The observed associations could probably be linked to an increase of serum levels of health\u2010beneficial molecules including free bilirubin.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>A predictive effect of UGT<\/jats:styled-content>1A<\/jats:italic> polymorphisms on HCC<\/jats:styled-content> risk was identified. If confirmed, these findings could contribute to improve the HCC<\/jats:styled-content> surveillance, treatment tailoring and patients care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13411","type":"journal-article","created":{"date-parts":[[2017,3,12]],"date-time":"2017-03-12T10:52:57Z","timestamp":1489315977000},"page":"1345-1353","source":"Crossref","is-referenced-by-count":20,"title":["UGT1A polymorphisms as genetic biomarkers for hepatocellular carcinoma risk in Caucasian population"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-8767","authenticated-orcid":false,"given":"Elena","family":"De Mattia","sequence":"first","affiliation":[{"name":"Clinical and Experimental Pharmacology CRO\u2010National Cancer Institute Aviano PN Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Cecchin","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Pharmacology CRO\u2010National Cancer Institute Aviano PN Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Polesel","sequence":"additional","affiliation":[{"name":"Unit of Cancer Epidemiology CRO\u2010National Cancer Institute Aviano PN Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Lupo","sequence":"additional","affiliation":[{"name":"General Surgery 2U and Liver Transplantation Center A.O.U. 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