{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:32:00Z","timestamp":1790281920934,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01AA021907"],"award-info":[{"award-number":["U01AA021907"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01AA021902"],"award-info":[{"award-number":["U01AA021902"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["F31AA025545"],"award-info":[{"award-number":["F31AA025545"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>Inflammation and impaired hepatocyte regeneration contribute to liver failure in alcoholic hepatitis (AH<\/jats:styled-content>). Interleukin (IL<\/jats:styled-content>)\u20101 is a key inflammatory cytokine in the pathobiology of AH<\/jats:styled-content>. The role of IL<\/jats:styled-content>\u20101 in liver regeneration in the recovery phase of alcohol\u2010induced liver injury is unknown.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this study, we tested IL<\/jats:styled-content>\u20101 receptor antagonist to block IL<\/jats:styled-content>\u20101 signalling in a mouse model of acute\u2010on\u2010chronic liver injury on liver inflammation and hepatocyte regeneration in AH<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>We observed that inhibition of IL<\/jats:styled-content>\u20101 signalling decreased liver inflammation and neutrophil infiltration, and resulted in enhanced regeneration of hepatocytes and increased rate of recovery from liver injury in AH<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our novel findings suggest that IL<\/jats:styled-content>\u20101 drives sustained liver inflammation and impaired hepatocyte regeneration even after cessation of ethanol exposure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13430","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T01:52:41Z","timestamp":1490579561000},"page":"968-973","source":"Crossref","is-referenced-by-count":63,"title":["Interleukin\u20101 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice"],"prefix":"10.1111","volume":"37","author":[{"given":"Arvin","family":"Iracheta\u2010Vellve","sequence":"first","affiliation":[{"name":"Department of Medicine University of Massachusetts Medical School Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Petrasek","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Massachusetts Medical School Worcester MA USA"},{"name":"Department of Medicine University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedek","family":"Gyogyosi","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Massachusetts Medical School Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi","family":"Bala","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Massachusetts Medical School Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timea","family":"Csak","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Massachusetts Medical School Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Kodys","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Massachusetts Medical School Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0836-2527","authenticated-orcid":false,"given":"Gyongyi","family":"Szabo","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Massachusetts Medical School Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308410"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21607"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.10.042"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-072610-145138"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.06.013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3AB1214-590R"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60777"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.736991"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28680"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308331110"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.032"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.2.309"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23640"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.35"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.505636"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10555"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33355"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2015.06.012"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2016.13"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.13430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.13430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:21:26Z","timestamp":1695572486000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.13430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,27]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/liv.13430"],"URL":"https:\/\/doi.org\/10.1111\/liv.13430","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,27]]}}}