{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:14:17Z","timestamp":1789704857844,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T00:00:00Z","timestamp":1506643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002738","name":"Assistance Publique - H\u00f4pitaux de Paris","doi-asserted-by":"publisher","award":["OST07008"],"award-info":[{"award-number":["OST07008"]}],"id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>The reliability of transient elastography (TE<\/jats:styled-content>) to assess liver fibrosis is insufficiently validated in alcoholic liver disease (ALD<\/jats:styled-content>). We aimed to validate the diagnostic utility of TE<\/jats:styled-content> for liver fibrosis in patients with excessive alcohol consumption and evaluate whether Fibrotest\u00ae<\/jats:sup> adds diagnostic value relative to or in combination with TE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted a multicentre prospective study on a total of 217 heavy drinkers with high serum aminotransferase levels. Patients underwent liver biopsy, TE<\/jats:styled-content>, Fibrotest\u00ae<\/jats:sup>, PGAA<\/jats:styled-content>, APRI<\/jats:styled-content>, FIB<\/jats:styled-content>\u20104 and FORNS<\/jats:styled-content>. The overall diagnostic performance was evaluated by the area under the receiver operating characteristic (AUROC<\/jats:styled-content>) curves and Obuchowski measures.<\/jats:p><\/jats:sec>Results<\/jats:title>TE<\/jats:styled-content> values correlated with fibrosis stage (r=.73; P<\/jats:italic><.0001) and steatosis stage (r=.19; P<\/jats:italic><.01). Patients with alcoholic hepatitis had higher TE<\/jats:styled-content> values than those without alcoholic hepatitis (P<\/jats:italic><.0001). In an multivariate analysis, fibrosis stage and the presence of alcoholic hepatitis were the only parameters that correlated with liver stiffness. For the diagnosis of advanced fibrosis (F\u22653), the AUROC<\/jats:styled-content> curves were 0.90, 0.85, 0.83, 0.91 and 0.90 for TE<\/jats:styled-content>, Fibrotest\u00ae<\/jats:sup>, PGAA<\/jats:styled-content> and associations TE<\/jats:styled-content>\u2010Fibrotest\u00ae<\/jats:sup>, TE<\/jats:styled-content>\u2010PGAA<\/jats:styled-content> respectively. For the diagnosis of cirrhosis, the AUROC<\/jats:styled-content> curves were 0.93, 0.88, 0.89, 0.94 and 0.95 respectively. The Obuchowski measures for the diagnosis of fibrosis were 0.94, 0.92, 0.91, 0.95 and 0.94 respectively. The performance of TE<\/jats:styled-content> was not significantly different than those of Fibrotest\u00ae<\/jats:sup>, PGAA<\/jats:styled-content> and combinations TE<\/jats:styled-content>\u2010Fibrotest\u00ae<\/jats:sup>, TE<\/jats:styled-content>\u2010PGAA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>TE<\/jats:styled-content> has excellent diagnostic value for liver fibrosis in alcoholic liver disease. The combined use of TE<\/jats:styled-content>\u2010Fibrotest\u00ae<\/jats:sup> or TE<\/jats:styled-content>\u2010PGAA<\/jats:styled-content> does not improve the performance of TE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13440","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T07:38:47Z","timestamp":1491550727000},"page":"1697-1705","source":"Crossref","is-referenced-by-count":48,"title":["Transient elastography alone and in combination with FibroTest\u00ae<\/sup> for the diagnosis of hepatic fibrosis in alcoholic liver disease"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7161-9631","authenticated-orcid":false,"given":"Cosmin Sebastian","family":"Voican","sequence":"first","affiliation":[{"name":"AP\u2010HP Service d'h\u00e9pato\u2010gastroent\u00e9rologie et nutrition H\u00f4pital Antoine B\u00e9cl\u00e8re Clamart France"},{"name":"INSERM U996 Labex Lermit IPSIT Clamart 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