{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T01:07:10Z","timestamp":1773709630506,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement","award":["2014_SGR_605"],"award-info":[{"award-number":["2014_SGR_605"]}]},{"name":"Spanish Health Ministry"},{"name":"CIBERehd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Hepatitis C (HCV) therapy with Sofosbuvir (SOF)\/Simeprevir (SMV) in clinical trials and real\u2010world clinical practice, showed high rates of sustained virological response (SVR) in non\u2010cirrhotic genotype (GT)\u20101 and GT\u20104 patients. These results were slightly lower in cirrhotic patients. We investigated real\u2010life effectiveness and safety of SOF\/SMV with or without ribavirin (RBV) in a large cohort of cirrhotic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This collaborative multicentre study included data from 968 patients with cirrhosis infected with HCV\u2010GT1 or 4, treated with SOF\/SMV\u00b1RBV in 30 centres across Spain between January\u20102014 and December\u20102015. Demographic, clinical, virological and safety data were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall SVR was 92.3%; the majority of patients were treated with RBV (62%) for 12\u00a0weeks (92.4%). No significant differences in SVR were observed between genotypes (GT1a:94.3%; GT1b:91.7%; GT4:91.1%). Those patients with more advanced liver disease (Child B\/C, MELD\u226510) or portal hypertension (platelet count\u2264100\u00d710<jats:sup>9<\/jats:sup>\/L, transient elastography\u226521\u00a0Kpa) showed significantly lower SVR rates (84.4%\u201091.9%) than patients with less advanced liver disease (93.8%\u201095.9%, <jats:italic>P<\/jats:italic>&lt;.01 in all cases). In the multivariate analysis, the use of RBV, female gender, baseline albumin\u226535\u00a0g\/L, MELD&lt;10 and lack of exposure to a triple therapy regimen were independent predictors of SVR (<jats:italic>P<\/jats:italic>&lt;.05). Serious adverse events (SAEs) and SAE\u2010associated discontinuation events occurred in 5.9% and 2.6%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this large cohort of cirrhotic patients managed in the real\u2010world setting in Spain, SOF\/SMV\u00b1RBV yielded to excellent SVR rates, especially in patients with compensated liver cirrhosis. In addition, this combination showed to be safe, with low rates of SAEs and early discontinuations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13470","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T15:22:43Z","timestamp":1494256963000},"page":"1823-1832","source":"Crossref","is-referenced-by-count":11,"title":["High efficacy of Sofosbuvir plus Simeprevir in a large cohort of Spanish cirrhotic patients infected with genotypes 1 and 4"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6321-9534","authenticated-orcid":false,"given":"Zoe","family":"Mari\u00f1o","sequence":"first","affiliation":[{"name":"Liver Unit Hospital Clinic University of Barcelona Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan 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