{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:20:10Z","timestamp":1793215210845,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,9]],"date-time":"2017-09-09T00:00:00Z","timestamp":1504915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32DK007769\u201015"],"award-info":[{"award-number":["5T32DK007769\u201015"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 CA163177"],"award-info":[{"award-number":["T32 CA163177"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>Portal vein thrombosis (PVT<\/jats:styled-content>) in cirrhosis may lead to hepatic decompensation and increased mortality. We aimed to investigate if decreased portal vein (PV<\/jats:styled-content>) velocity is associated with future PVT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data on adult patients with cirrhosis and PVT<\/jats:styled-content> between January 1, 2005 and July 30, 2015 were obtained. Cases with PVT<\/jats:styled-content> were matched by age, gender and Model for End\u2010stage Liver Disease (MELD<\/jats:styled-content>) score to corresponding controls without PVT<\/jats:styled-content>. Cox proportional hazards models, receiver operator curves and Kaplan Meier curves were constructed.<\/jats:p><\/jats:sec>Results<\/jats:title>One hundred subjects (50 matched pairs) with mean age 53.8\u00b113.1\u00a0y and MELD<\/jats:styled-content> score 14.9\u00b15.5 were included in our analysis. Sixty\u2010four percent were male and 76% were Child\u2010Turcotte\u2010Pugh Class A or B. Baseline characteristics (prior to development of PVT<\/jats:styled-content>) were similar, except for baseline PV<\/jats:styled-content> velocity (16.9\u00a0cm\/s, 95% CI<\/jats:styled-content> 13.9\u201020.0 PVT<\/jats:styled-content> vs 25.0, 95% CI<\/jats:styled-content> 21.8\u201028.8 no PVT<\/jats:styled-content>, P<\/jats:italic><.001). 30 PVT<\/jats:styled-content> subjects had PV<\/jats:styled-content> velocity <15\u00a0cm\/s compared to five without PVT<\/jats:styled-content> (P<\/jats:italic><.001). On adjusted multivariable analysis, PV<\/jats:styled-content> velocity was the strongest independent risk factor predicting PVT<\/jats:styled-content> development (HR<\/jats:styled-content> 0.86, 95% CI<\/jats:styled-content> 0.80\u20100.93). The predictive value for PVT<\/jats:styled-content> development was greatest for flow <15\u00a0cm\/s (c\u2010statistic 0.77). PV<\/jats:styled-content> velocity <15\u00a0cm\/s had a highly significant association with future PVT<\/jats:styled-content> (HR<\/jats:styled-content> 6.00, 95% CI<\/jats:styled-content> 2.20\u201016.40, P<\/jats:italic>=<.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Decreased PV<\/jats:styled-content> velocity is associated with increased risk of future PVT<\/jats:styled-content>. Patients with cirrhosis and decreased PV<\/jats:styled-content> velocity are a high\u2010risk subgroup that warrants further investigation with prospective study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13500","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T16:46:39Z","timestamp":1497977199000},"page":"94-101","source":"Crossref","is-referenced-by-count":147,"title":["Decreased portal vein velocity is predictive of the development of portal vein thrombosis: A matched case\u2010control study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3352-6928","authenticated-orcid":false,"given":"Jonathan G.","family":"Stine","sequence":"first","affiliation":[{"name":"Center for the Study of Coagulation Disorders in Liver Disease Division of Gastroenterology & Hepatology Department of Medicine University of Virginia Charlottesville VA 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Medicine University of Virginia Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Uflacker","sequence":"additional","affiliation":[{"name":"Division of Interventional Radiology Department of Radiology University of Virginia Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Caldwell","sequence":"additional","affiliation":[{"name":"Center for the Study of Coagulation Disorders in Liver Disease Division of Gastroenterology & Hepatology Department of Medicine University of Virginia Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick G.","family":"Northup","sequence":"additional","affiliation":[{"name":"Center for the Study of Coagulation Disorders in Liver Disease Division of Gastroenterology & Hepatology Department of Medicine University of Virginia Charlottesville VA 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