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Using data from the Chronic Hepatitis Cohort Study (<jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content>e<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>), we identified points at which the trend significantly changed, and estimated the annual percent change (<jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content>) in rates of cirrhosis, decompensated cirrhosis and all\u2010cause mortality, adjusted by race, sex and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 11,167 adults with chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection, prevalence of cirrhosis increased from 20.8% to 27.6% from 2006 to 2015, with adjusted annual percentage change (<jats:styled-content style=\"fixed-case\">aAPC<\/jats:styled-content>) of 1.2 (<jats:italic>p<\/jats:italic>\u00a0&lt;.\u00a001). Although incidence of all\u2010cause mortality increased from 1.8% in 2006 to 2.9% in 2015, a join\u2010point was identified at 2010, with <jats:styled-content style=\"fixed-case\">aAPC<\/jats:styled-content>s of 9.6 before (2006\u00a0&lt;\u00a02010; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) and \u22125.2 after (2010\u00a0\u2264\u00a02015; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01), indicating a decrease in mortality from 2010 and onward. Likewise, overall prevalence of decompensated cirrhosis increased from 9.3% in 2006 to 10.4% in 2015, but this increase was confined to patients 60 or older (<jats:styled-content style=\"fixed-case\">aAPC<\/jats:styled-content>\u00a0=\u00a01.5; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.023). Asian American and Black\/African American patients demonstrated significantly higher rates of cirrhosis than White patients, while older patients and men demonstrated higher rates of cirrhosis and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although cirrhosis and mortality among <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected patients in the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> have increased over the past decade, all\u2010cause mortality has decreased in recent years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13501","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T19:52:49Z","timestamp":1498074769000},"page":"239-247","source":"Crossref","is-referenced-by-count":9,"title":["Changing trends in complications of chronic hepatitis C"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3313-6428","authenticated-orcid":false,"given":"Mei","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loralee B.","family":"Rupp","sequence":"additional","affiliation":[{"name":"Center for Health Policy and Health Services Research Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueren","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott D.","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis National Center for HIV, Hepatitis, STD, and TB Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne C.","family":"Moorman","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis National Center for HIV, Hepatitis, STD, and TB Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip R.","family":"Spradling","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis National Center for HIV, Hepatitis, STD, and TB Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyasu H.","family":"Teshale","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis National Center for HIV, Hepatitis, STD, and TB Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A.","family":"Boscarino","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Services Research Geisinger Health System  Danville PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihe G.","family":"Daida","sequence":"additional","affiliation":[{"name":"Center for Health Research Kaiser Permanente\u2013Hawai'i  Honolulu HI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Center for Health Research Kaiser Permanente\u2013Northwest  Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheri","family":"Trudeau","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart C.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27978"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit245"},{"key":"e_1_2_10_4_1","unstructured":"Prevention CFDCA.Viral hepatitis; Centers for Disease Control and\u00a0Prevention.https:\/\/www.cdc.gov\/hepatitis\/hcv\/guidelinesc.htm. 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