{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:37:47Z","timestamp":1780594667204,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T00:00:00Z","timestamp":1501286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Alterations in body composition (BC<\/jats:styled-content>) as loss of fat and muscle mass (sarcopenia) are associated with poor outcome in alcoholic cirrhosis (ALC<\/jats:styled-content>). Prevalence of sarcopenia depends upon the method of assessment. Computed Tomography (CT<\/jats:styled-content>) is a gold standard tool for assessing BC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Aim<\/jats:title>To characterize BC<\/jats:styled-content> and define sarcopenia in ALC<\/jats:styled-content> patients using CT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Single slice CT<\/jats:styled-content> images at L3 vertebrae of healthy controls (HC<\/jats:styled-content>) \u2010 organ transplant donors and ALC<\/jats:styled-content> patients were analysed to give cross\u2010sectional area of five skeletal muscles normalized for height \u2010skeletal muscle index (SMI<\/jats:styled-content>; cm2<\/jats:sup>\/m2<\/jats:sup>), area of subcutaneous (SAT<\/jats:styled-content>;cm2<\/jats:sup>) and visceral adipose tissue (VAT<\/jats:styled-content>;cm2<\/jats:sup>). Cut\u2010offs for defining sarcopenia was established at 2SD<\/jats:styled-content> below the mean of HC<\/jats:styled-content>. HC<\/jats:styled-content> were compared with Child A\u2014compensated (C) and Child B+C\u2014decompensated (DC<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec>Results<\/jats:title>Cut\u2010offs of SMI<\/jats:styled-content> derived from HC<\/jats:styled-content> (n\u00a0=\u00a0275; M: 50%; age 32.2\u00a0\u00b1\u00a09.8\u00a0years; BMI<\/jats:styled-content> 24.2\u00a0\u00b1\u00a03.2\u00a0Kg\/m2<\/jats:sup>) were 36.54 in males and 30.21 in females. Sarcopenia was found in 12.8% of ALC<\/jats:styled-content> patients [n\u00a0=\u00a0148; C (31.8%): DC<\/jats:styled-content> (68.2%); M: 100%; age 46.6\u00a0\u00b1\u00a09.7\u00a0years; BMI<\/jats:styled-content> 24.5\u00a0\u00b1\u00a04.4]. Compared to HC<\/jats:styled-content>, compensated patients had higher adiposity and comparable muscularity; decompensated patients had significantly lower muscle and also fat mass compared to both HC<\/jats:styled-content> and compensated patients. HC<\/jats:styled-content> vs C vs DC<\/jats:styled-content>: SAT<\/jats:styled-content> (140\u00a0\u00b1\u00a082 vs 177.3\u00a0\u00b1\u00a011 vs 112\u00a0\u00b1\u00a08.2); VAT<\/jats:styled-content> (96.5\u00a0\u00b1\u00a06.5 vs 154.9\u00a0\u00b1\u00a08.7 vs 87.5\u00a0\u00b1\u00a06.5) and SMI<\/jats:styled-content> (52.1\u00a0\u00b1\u00a00.9 vs 49.6\u00a0\u00b1\u00a01.2 vs 46\u00a0\u00b1\u00a00.9).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Compensated ALC<\/jats:styled-content> have increased adiposity and relatively preserved muscularity but decompensation leads to loss of both muscle and fat mass. Prevalence of sarcopenia, based on derived ethnic cut\u2010offs was 12.8%.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13509","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T15:52:38Z","timestamp":1498837958000},"page":"1668-1674","source":"Crossref","is-referenced-by-count":62,"title":["Characterization of body composition and definition of sarcopenia in patients with alcoholic cirrhosis: A computed tomography based study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7664-2603","authenticated-orcid":false,"given":"Jaya","family":"Benjamin","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition Institute of Liver and Biliary Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Shasthry","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Institute of Liver and Biliary Sciences New Delhi 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