{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:45:03Z","timestamp":1791773103402,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T00:00:00Z","timestamp":1506729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>\n \n Background & Aims<\/jats:title>\n Recent studies suggest that heparins reduce liver fibrosis and the risk of decompensation of liver disease. Here, we evaluated the effects of enoxaparin in several experimental models of advanced cirrhosis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Cirrhosis was induced in male Sprague\u2010Dawley (\n SD<\/jats:styled-content>\n ) rats by: (i) Oral gavage with carbon tetrachloride (\n CC<\/jats:styled-content>\n l4\n \n ORAL<\/jats:sub>\n <\/jats:styled-content>\n ), (ii) Bile duct ligation (\n BDL<\/jats:styled-content>\n ) and (iii)\n CC<\/jats:styled-content>\n l4 inhalation (\n CC<\/jats:styled-content>\n l4\n \n INH<\/jats:sub>\n <\/jats:styled-content>\n ). Rats received saline or enoxaparin s.c. (40\u00a0\n IU<\/jats:styled-content>\n \/Kg\/d or 180\u00a0\n IU<\/jats:styled-content>\n \/Kg\/d) following various protocols. Blood biochemical parameters, liver fibrosis, endothelium\u2010 and fibrosis\u2010related genes, portal pressure, splenomegaly, bacterial translocation, systemic inflammation and survival were evaluated. Endothelial dysfunction was assessed by in situ bivascular liver perfusions.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Enoxaparin did not ameliorate liver function, liver fibrosis, profibrogenic gene expression, portal hypertension, splenomegaly, ascites development and infection, serum\n IL<\/jats:styled-content>\n \u20106 levels or survival in rats with\n CC<\/jats:styled-content>\n l4\n \n ORAL<\/jats:sub>\n <\/jats:styled-content>\n or\n BDL<\/jats:styled-content>\n \u2010induced cirrhosis. Contrarily, enoxaparin worsened portal pressure in\n BDL<\/jats:styled-content>\n rats and decreased survival in\n CC<\/jats:styled-content>\n l4\n \n ORAL<\/jats:sub>\n <\/jats:styled-content>\n rats. In\n CC<\/jats:styled-content>\n l4\n \n INH<\/jats:sub>\n <\/jats:styled-content>\n rats, enoxaparin had no effects on hepatic endothelial dysfunction, except for correcting the hepatic arterial dysfunction when enoxaparin was started with the\n CC<\/jats:styled-content>\n l4 exposure. In these rats, however, enoxaparin increased liver fibrosis and the absolute values of portal venous and sinusoidal resistance.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Our results do not support a role of enoxaparin for improving liver fibrosis, portal hypertension or endothelial dysfunction in active disease at advanced stages of cirrhosis. These disease\u2010related factors and the possibility of a limited therapeutic window should be considered in future studies evaluating the use of anticoagulants in cirrhosis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.13510","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T11:52:51Z","timestamp":1498823571000},"page":"102-112","source":"Crossref","is-referenced-by-count":22,"title":["Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis"],"prefix":"10.1111","volume":"38","author":[{"given":"Jos\u00e9 I.","family":"Fortea","sequence":"first","affiliation":[{"name":"Laboratorio Investigaci\u00f3n Hepatolog\u00eda y Gastroenterolog\u00eda HGU Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Instituto Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) Madrid 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