{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T01:50:43Z","timestamp":1746323443455,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Cellulitis is a common infection in patients with cirrhosis but its impact on progression of liver disease has been hardly addressed. This study examines the incidence of acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>), predictive factors and its impacts on mortality in cirrhotic patients hospitalized for cellulitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective data from cirrhotic patients hospitalized for cellulitis over the period January 2006 to September 2015 were analysed. <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> was defined according to revised criteria of the International Club of Ascites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 101 episodes of cellulitis were examined (70.3% men; mean age 60.6\u00a0\u00b1\u00a013.6\u00a0years). Of patients, 27% met criteria for acute on chronic liver failure (<jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content>) (grade 1: 63%; grade 2: 22%; grade 3: 15%). <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> was recorded in 50.5% (type 1: 67%; type 2: 19%; type 3: 14%). <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> was present on admission in 21 of the 51 patients (41%) who developed it. In the remaining 30 patients (59%), <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> appeared during hospitalization and its development was associated with a <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> score &gt;14 (70% vs 30%, <jats:italic>P<\/jats:italic>=.024). In\u2010hospital mortality was 10% and all patients who died had <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>. A high <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> score on admission, <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> were associated with in\u2010hospital mortality (<jats:italic>P<\/jats:italic>&lt;.05). One\u2010month transplant\u2010free survival was 84% (70% vs 98% in patients with and without <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>,<jats:italic> P<\/jats:italic>=.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In cirrhotic patients, cellulitis is a serious infection that often leads to <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> is a strong predictor of mortality in this setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13515","type":"journal-article","created":{"date-parts":[[2017,7,8]],"date-time":"2017-07-08T07:56:40Z","timestamp":1499500600000},"page":"285-294","source":"Crossref","is-referenced-by-count":6,"title":["Incidence, predictive factors and impacts of acute kidney injury in cirrhotic patients hospitalized for cellulitis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5498-6280","authenticated-orcid":false,"given":"Ana","family":"Garcia Garcia de Paredes","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hospital Universitario Ram\u00f3n y Cajal IRYCIS Universidad de Alcal\u00e1  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Tellez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hospital Universitario Ram\u00f3n y Cajal IRYCIS Universidad de Alcal\u00e1  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Angel","family":"Rodriguez\u2010Gandia","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hospital Universitario Ram\u00f3n y Cajal IRYCIS Universidad de Alcal\u00e1  Madrid 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