{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:58:35Z","timestamp":1793336315860,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Inflammatory bowel disease (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>) may be complicated by primary sclerosing cholangitis (<jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>). We aimed to assess the characteristics of Danish <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients and to compare their prognosis with <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients without <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective nationwide population\u2010based cohort of 257 <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients was assessed through Danish national registries and manual scrutiny of patient files.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For all <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients diagnosed after 1976 (n\u00a0=\u00a0222) and 8231 <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> controls (ie, without <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>), the cumulative probability of resective surgery, liver transplantation, cancer, and survival from 1977 through 2011 was estimated and compared by log\u2010rank test and Cox regression. <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients primarily had ulcerative colitis (<jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>) (72%), were diagnosed in young adulthood (median age at <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> diagnosis, 23\u00a0years), and 9% were smokers. Among <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> patients 78% had pancolitis at diagnosis. Among patients with <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> and Crohn's disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) 91% had colonic involvement. The <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients had a significantly higher probability of receiving resective surgery (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>; 2.13, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.50\u20103.03); of developing colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>; 21.4, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 9.6\u201047.6), of cholangiocarcinoma (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>; 190, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 54.8\u2010660), and of dying (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>; 4.39, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 3.22\u20106.00) as compared to non\u2010<jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> controls. The 25\u2010year cumulative risk of liver transplantation was high (53%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This unselected population\u2010based study shows that <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients not only have an extensive phenotype of <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>, they are also treated more intensively than other patients with <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>. However, the prognosis remains poor and without any apparent improvement over calendar time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13548","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T10:13:02Z","timestamp":1502359982000},"page":"532-541","source":"Crossref","is-referenced-by-count":81,"title":["Inflammatory bowel disease with primary sclerosing cholangitis: A Danish population\u2010based cohort study 1977\u20102011"],"prefix":"10.1111","volume":"38","author":[{"given":"Jakob \u00d8rskov","family":"S\u00f8rensen","sequence":"first","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4612-8635","authenticated-orcid":false,"given":"Ole Haagen","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Herlev Hospital University of Copenhagen  Herlev 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