{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:45:17Z","timestamp":1790851517917,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Abstract<\/jats:title>\n \n Background & Aims<\/jats:title>\n \n Hepatitis B Virus (\n HBV<\/jats:styled-content>\n )\n DNA<\/jats:styled-content>\n during chronic infection can reach levels at which mother\u2010to\u2010child (\n MTC<\/jats:styled-content>\n ) transmission frequently occurs despite passive\u2010active immunization of newborns. Hepatitis D Virus (\n HDV<\/jats:styled-content>\n )\n RNA<\/jats:styled-content>\n can reach high levels, we assessed\n HBV<\/jats:styled-content>\n \/\n HDV MTC<\/jats:styled-content>\n co\u2010transmission.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Monocentric retrospective study (registered in ClinicalTrials.gov (\n NCT<\/jats:styled-content>\n 02044055)), after informed consent in\n HBV<\/jats:styled-content>\n \/\n HDV<\/jats:styled-content>\n co\u2010infected women pregnant between 01\/01\/2004 and 01\/01\/2015 in Paris, France. The children were tested when 24\u00a0months of age or older.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twenty\u2010two (3%) of 742\n HBV<\/jats:styled-content>\n infected women,\n HDV<\/jats:styled-content>\n co\u2010infected, gave birth to 54 children during the study period.\n HBV DNA<\/jats:styled-content>\n was above 5 Log\n 10<\/jats:sub>\n I.U\/\n mL<\/jats:styled-content>\n in 10 pregnancies previous any treatment, with\n HDV RNA<\/jats:styled-content>\n of less than 2.3 Log\n 10<\/jats:sub>\n I.U\/\n mL<\/jats:styled-content>\n .\n HDV RNA<\/jats:styled-content>\n was above 5 Log\n 10<\/jats:sub>\n I.U\/\n mL<\/jats:styled-content>\n in eight pregnancies previous any treatment, with\n HBV DNA<\/jats:styled-content>\n of less than 1.5 Log\n 10<\/jats:sub>\n I.U\/\n mL<\/jats:styled-content>\n . Inverse patterns of\n HBV DNA<\/jats:styled-content>\n and\n HDV RNA<\/jats:styled-content>\n were observed in 17 of 35 (49%) pregnancies: 13 (76%) received no\n HBV<\/jats:styled-content>\n treatment; four (24%) were treated.\n HBV DNA<\/jats:styled-content>\n was under 5 Log\n 10<\/jats:sub>\n I.U\/\n mL<\/jats:styled-content>\n in 46 of the 50 assessed women (92%) at birth. Of the 36 assessed children, given passive\u2010active immunization, 24 (66%) were protected, 10 (28%) were neither infected nor protected, one was chronically\n HBV<\/jats:styled-content>\n infected, and one had a past\n HBV<\/jats:styled-content>\n infection.\n HDV<\/jats:styled-content>\n Ab was negative in the 36 children.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These results suggest that\n HBV<\/jats:styled-content>\n \/\n HDV MTC<\/jats:styled-content>\n co\u2010transmission is exceptional. Studies are needed, mainly in developing countries.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.13556","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T09:42:43Z","timestamp":1503481363000},"page":"611-618","source":"Crossref","is-referenced-by-count":49,"title":["Hepatitis B Virus\u2010Hepatitis D Virus mother\u2010to\u2010child co\u2010transmission: A retrospective study in a developed country"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3619-3110","authenticated-orcid":false,"given":"Pierre O.","family":"Sellier","sequence":"first","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Interne GH Saint\u2010Louis\/Lariboisi\u00e8re\u2010Fernand Widal, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Maylin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de microbiologie GH Saint\u2010Louis\/Lariboisi\u00e8re\u2010Fernand Widal, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9gol\u00e8ne","family":"Brichler","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie CNR des h\u00e9patites delta H\u00f4pital Avicenne, AP\u2010HP Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Ber\u00e7ot","sequence":"additional","affiliation":[{"name":"D\u00e9partement de microbiologie GH Saint\u2010Louis\/Lariboisi\u00e8re\u2010Fernand Widal, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Lopes","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Interne GH Saint\u2010Louis\/Lariboisi\u00e8re\u2010Fernand Widal, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroth\u00e9e","family":"Chopin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine 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