{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:00:55Z","timestamp":1769500855018,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2016R1A1A1A05005138"],"award-info":[{"award-number":["2016R1A1A1A05005138"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>Several risk prediction models for hepatocellular carcinoma (HCC<\/jats:styled-content>) development are available. We explored whether the use of risk prediction models can dynamically predict HCC<\/jats:styled-content> development at different time points in chronic hepatitis B (CHB<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Between 2006 and 2014, 1397 CHB<\/jats:styled-content> patients were recruited. All patients underwent serial transient elastography at intervals of >6\u00a0months.<\/jats:p><\/jats:sec>Results<\/jats:title>The median age of this study population (931 males and 466 females) was 49.0\u00a0years. The median CU<\/jats:styled-content>\u2010HCC<\/jats:styled-content>, REACH<\/jats:styled-content>\u2010B, LSM<\/jats:styled-content>\u2010HCC<\/jats:styled-content> and mREACH<\/jats:styled-content>\u2010B score at enrolment were 4.0, 9.0, 10.0 and 8.0 respectively. During the follow\u2010up period (median, 68.0\u00a0months), 87 (6.2%) patients developed HCC<\/jats:styled-content>. All risk prediction models were successful in predicting HCC<\/jats:styled-content> development at both the first liver stiffness (LS<\/jats:styled-content>) measurement (hazard ratio [HR<\/jats:styled-content>]\u00a0=\u00a01.067\u20101.467 in the subgroup without antiviral therapy [AVT<\/jats:styled-content>] and 1.096\u20101.458 in the subgroup with AVT<\/jats:styled-content>) and second LS<\/jats:styled-content> measurement (HR<\/jats:styled-content>\u00a0=\u00a01.125\u20101.448 in the subgroup without AVT<\/jats:styled-content> and 1.087\u20101.249 in the subgroup with AVT<\/jats:styled-content>). In contrast, neither the absolute nor percentage change in the scores from the risk prediction models predicted HCC<\/jats:styled-content> development (all P\u00a0<\/jats:italic>>\u00a0<\/jats:italic>.05). The mREACH<\/jats:styled-content>\u2010B score performed similarly or significantly better than did the other scores (AUROC<\/jats:styled-content>s at 5\u00a0years, 0.694\u20100.862 vs 0.537\u20100.875).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Dynamic prediction of HCC<\/jats:styled-content> development at different time points was achieved using four risk prediction models, but not using the changes in the absolute and percentage values between two time points. The mREACH<\/jats:styled-content>\u2010B score was the most appropriate prediction model of HCC<\/jats:styled-content> development among four prediction models.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13583","type":"journal-article","created":{"date-parts":[[2017,9,2]],"date-time":"2017-09-02T13:26:36Z","timestamp":1504358796000},"page":"676-686","source":"Crossref","is-referenced-by-count":25,"title":["Feasibility of dynamic risk prediction for hepatocellular carcinoma development in patients with chronic hepatitis B"],"prefix":"10.1111","volume":"38","author":[{"given":"Mi Young","family":"Jeon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9658-8050","authenticated-orcid":false,"given":"Seung Up","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beom Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6324-2224","authenticated-orcid":false,"given":"Jun Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang\u2010Hyub","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333258"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28156"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.02.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307023"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23684"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28115"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i39.6515"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70077-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.019"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051287"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.07.023"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29537"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2016.22.1.18"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3350\/kjhep.2012.18.1.1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.05.039"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.035"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.10.033"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.157"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.04.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31829a7247"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24121"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.06.019"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27069"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.13583","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.13583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T17:00:02Z","timestamp":1695574802000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.13583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,20]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/liv.13583"],"URL":"https:\/\/doi.org\/10.1111\/liv.13583","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,20]]}}}