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Many patients with\n                    <jats:styled-content style=\"fixed-case\">CLD<\/jats:styled-content>\n                    are diagnosed between the ages of 20\u201050\u00a0years, a particularly productive period of life professionally, biologically and in other respects; it is not surprising, thus, that\n                    <jats:styled-content style=\"fixed-case\">CLD<\/jats:styled-content>\n                    is often associated with impaired health\u2010related quality of life (\n                    <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content>\n                    ) and uncertainty regarding implications for and outcomes of pregnancy. Primary sclerosing cholangitis (\n                    <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\n                    ) and primary biliary cholangitis (\n                    <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>\n                    ) are the most prominent\n                    <jats:styled-content style=\"fixed-case\">CLD<\/jats:styled-content>\n                    s, both having considerable morbidity and mortality and representing major indications for liver transplantation. These disorders, as a consequence of their complications (eg ascites, hepatic osteodystrophy), associated conditions (eg inflammatory bowel disease) and symptoms (eg pruritus and fatigue), can significantly impair an array of domains of\n                    <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content>\n                    . Here we review these impactful clinical aspects of\n                    <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>\n                    as well as the topics of fertility and pregnancy.\n                  <\/jats:p>","DOI":"10.1111\/liv.13591","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T10:37:51Z","timestamp":1505731071000},"page":"399-411","source":"Crossref","is-referenced-by-count":32,"title":["Complications, symptoms, quality of life and pregnancy in cholestatic liver disease"],"prefix":"10.1111","volume":"38","author":[{"given":"Kais","family":"Zakharia","sequence":"first","affiliation":[{"name":"Internal Medicine Residency Program Beaumont Health \u2013 Dearborn  Dearborn MI 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