{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:29:48Z","timestamp":1768292988517,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T00:00:00Z","timestamp":1509926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB\u2010TRR57"],"award-info":[{"award-number":["SFB\u2010TRR57"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["668031"],"award-info":[{"award-number":["668031"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>CXCR<\/jats:styled-content>% ligands play an important role in hepatic injury, inflammation and fibrosis. While CXCL<\/jats:styled-content>9 and CXCL<\/jats:styled-content>11 are associated with survival in patients receiving transjugular intrahepatic portosystemic shunt (TIPS<\/jats:styled-content>), the role of CXCL<\/jats:styled-content>10 in severe portal hypertension remains unknown.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 89 cirrhotic patients were analysed. CXCL<\/jats:styled-content>10 protein levels were measured in portal and hepatic blood at TIPS<\/jats:styled-content> insertion and 2\u00a0weeks later in 24 patients. CXCL<\/jats:styled-content>10 and IL<\/jats:styled-content>8 levels were assessed in portal, hepatic, cubital vein and right atrium blood in a further 25 patients at TIPS<\/jats:styled-content> insertion. Furthermore, real\u2010time PCR<\/jats:styled-content> determined hepatic CXCL<\/jats:styled-content>10\u2010mRNA<\/jats:styled-content> in 40 cirrhotic patients.<\/jats:p><\/jats:sec>Results<\/jats:title>Hepatic CXCL<\/jats:styled-content>10 showed no association with decompensation. By contrast, circulating CXCL<\/jats:styled-content>10\u2010levels were higher in portal than in hepatic vein blood, suggesting an extrahepatic source of CXCL<\/jats:styled-content>10 in cirrhosis. However, CXCL<\/jats:styled-content>10 protein in blood samples from portal, hepatic, cubital veins and right atrium correlated excellently with each other and with IL<\/jats:styled-content>\u20108 levels. Higher CXCL<\/jats:styled-content>10 circulating levels were associated with presence of ascites and higher Child scores. Higher CXCL<\/jats:styled-content>10 circulating protein levels were associated with acute decompensation, acute\u2010on\u2010chronic liver failure (ACLF<\/jats:styled-content>) and independently with mortality. Moreover, a decrease in CXCL<\/jats:styled-content>10 protein levels after TIPS<\/jats:styled-content> insertion was associated with better survival in each cohort and analysed together.<\/jats:p><\/jats:sec>Discussion<\/jats:title>Circulating CXCL<\/jats:styled-content>10 possibly reflects systemic inflammation and it is correlated with acute decompensation, ACLF<\/jats:styled-content> and complications in patients with severe portal hypertension receiving TIPS<\/jats:styled-content>. CXCL<\/jats:styled-content>10 predicts survival in these patients and a decrease in CXCL<\/jats:styled-content>10 after TIPS<\/jats:styled-content> may be considered a good prognostic factor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13610","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T13:28:42Z","timestamp":1509974922000},"page":"875-884","source":"Crossref","is-referenced-by-count":40,"title":["Circulating CXCL<\/scp>10 in cirrhotic portal hypertension might reflect systemic inflammation and predict ACLF<\/scp> and mortality"],"prefix":"10.1111","volume":"38","author":[{"given":"Jennifer M.","family":"Lehmann","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I University Clinic Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Claus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Clinic Bonn Bonn 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