{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T22:50:45Z","timestamp":1771887045551,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T00:00:00Z","timestamp":1512172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007170","name":"Ministry of Economy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/02010"],"award-info":[{"award-number":["PI15\/02010"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Therapies for hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection have revolutionized the treatment of patients with chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection. The effect of these therapies on the epidemiology of liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>) has yet to be elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To establish whether the indications for <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> have changed as a result of the introduction of new therapies for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We conducted a retrospective study based on a prospectively maintained registry of patients who undergo <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> at La Fe Hospital in Valencia from 1997 to 2016. An analysis of outcome measures over time stratified by <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> indications was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From January 1997 to December 2016, 2379 patients were listed for <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>. Of these, 1113 (47%) were listed for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> cirrhosis\u00b1hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>). This percentage varied significantly over time declining from 48.8% in the 1997\u20102009 initial period (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010based regimens) to 33% in the 2014\u20102016 final period (<jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s regimens) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). However, during that period, the proportion of those included in the waiting list (<jats:styled-content style=\"fixed-case\">WL<\/jats:styled-content>) due to <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> increased significantly (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). In addition, among <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010positive waitlisted patients with decompensated cirrhosis without <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>, the proportion of those with an <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010alcohol mixed etiology also increased significantly over time (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). Of all <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010positive waitlisted patients, 203 were eventually removed from the <jats:styled-content style=\"fixed-case\">WL<\/jats:styled-content> due to either clinical improvement (n\u00a0=\u00a077) or more frequently worsening\/death (n\u00a0=\u00a0126).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The proportion of patients wait\u2010listed for <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> for decompensated <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> cirrhosis has significantly decreased over time. These changes are possibly related to the large\u2010scale use of direct\u2010acting antivirals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13618","type":"journal-article","created":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T08:42:38Z","timestamp":1509784958000},"page":"1022-1027","source":"Crossref","is-referenced-by-count":23,"title":["Impact of hepatitis C virus (<scp>HCV<\/scp>) antiviral treatment on the need for liver transplantation (<scp>LT<\/scp>)"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9042-2308","authenticated-orcid":false,"given":"Esteban","family":"S\u00e1ez\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Liver Transplantation Unit Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Vinaixa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Liver Transplantation Unit Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria (IIS La Fe) Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"San Juan","sequence":"additional","affiliation":[{"name":"Unit of Hepato\u2010Biliary\u2010Pancreatic Surgery and Transplantation Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanesa","family":"Hontangas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Liver Transplantation Unit Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria (IIS La Fe) Hospital Universitari i Polit\u00e8cnic La Fe  Valencia 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Digestive Diseases (CIBEREHD)  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Rub\u00edn","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Liver Transplantation Unit Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria (IIS La Fe) Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Liver Transplantation Unit Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria (IIS La Fe) Hospital Universitari i Polit\u00e8cnic La Fe  Valencia 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