{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:19:36Z","timestamp":1773299976557,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T00:00:00Z","timestamp":1510531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["02\u20102013\u2010043"],"award-info":[{"award-number":["02\u20102013\u2010043"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>Hepatic iron overload is associated with liver injury and hepatocarcinogenesis; however, it has not been evaluated in patients with hepatocellular carcinoma (HCC<\/jats:styled-content>) in Asia. The aim of this study was to clarify the degree and distribution of intrahepatic iron deposition, and their effects on the survival of HCC<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Intrahepatic iron deposition was examined using non\u2010tumorous liver tissues from 204 HCC<\/jats:styled-content> patients after curative resection, and they were scored by 2 semi\u2010quantitative methods: simplified Scheuer's and modified Deugnier's methods. For the Scheuer's method, iron deposition in hepatocytes and Kupffer cells was separately evaluated, while for the modified Deugnier's method, hepatocyte iron score (HIS<\/jats:styled-content>), sinusoidal iron score (SIS<\/jats:styled-content>) and portal iron score (PIS<\/jats:styled-content>) were systematically evaluated, and the corrected total iron score (cTIS<\/jats:styled-content>) was calculated by multiplying the sum (TIS<\/jats:styled-content>) of the HIS<\/jats:styled-content>, SIS<\/jats:styled-content>, and PIS<\/jats:styled-content> by the coefficient.<\/jats:p><\/jats:sec>Results<\/jats:title>The overall prevalence of hepatic iron was 40.7% with the simplified Scheuer's method and 45.1% with the modified Deugnier's method with a mean cTIS<\/jats:styled-content> score of 2.46. During a median follow\u2010up of 67\u00a0months, the cTIS<\/jats:styled-content> was not associated with overall survival. However, a positive PIS<\/jats:styled-content> was significantly associated with a lower 5\u2010year overall survival rate (50.0%) compared with a negative PIS<\/jats:styled-content> (73.7%, P<\/jats:italic>\u00a0=\u00a0.006). In the multivariate analysis, a positive PIS<\/jats:styled-content> was an independent factor for overall mortality (hazard ratio, 2.310; 95% confidence interval, 1.181\u20104.517).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Intrahepatic iron deposition was common, and iron overload in the portal tract indicated poor survival in curatively resected HCC<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13619","type":"journal-article","created":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T08:02:37Z","timestamp":1509782557000},"page":"903-914","source":"Crossref","is-referenced-by-count":11,"title":["Hepatic iron overload in the portal tract predicts poor survival in hepatocellular carcinoma after curative resection"],"prefix":"10.1111","volume":"38","author":[{"given":"Jung Wha","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pathology Hallym University Dongtan Sacred Heart Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haeryoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Hospital Seoul National University College of Medicine Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho\u2010Seong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Surgery Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai Young","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Surgery Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Rok","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukho","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Sun","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0934-3344","authenticated-orcid":false,"given":"Jin\u2010Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-7990","authenticated-orcid":false,"given":"Sook\u2010Hyang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-923315"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22506"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v2.i2.65"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v2.i5.171"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041534"},{"key":"e_1_2_8_7_1","first-page":"371","article-title":"Histochemical detection of hepatic iron. 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