{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T20:27:54Z","timestamp":1775334474286,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:00:00Z","timestamp":1511913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Key Technologies R&D Program","award":["2015BAI13B09"],"award-info":[{"award-number":["2015BAI13B09"]}]},{"name":"Key Project from Beijing Municipal Science and Technology Commission","award":["D161100002716003"],"award-info":[{"award-number":["D161100002716003"]}]},{"name":"Key Project from Beijing Municipal Science and Technology Commission","award":["Z171100002217082"],"award-info":[{"award-number":["Z171100002217082"]}]},{"name":"Beijing Talents Fund","award":["2016000021469G226"],"award-info":[{"award-number":["2016000021469G226"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>It is unclear whether liver stiffness measurement (LSM<\/jats:styled-content>) dynamic changes after anti\u2010HBV<\/jats:styled-content> treatment could predict the risk of liver\u2010related events (LRE<\/jats:styled-content>s), particularly in patients with HBV<\/jats:styled-content>\u2010related compensated cirrhosis.<\/jats:p><\/jats:sec>Methods<\/jats:title>Treatment\u2010na\u00efve patients with HBV<\/jats:styled-content>\u2010related compensated cirrhosis were enrolled. All patients were under entecavir\u2010based antiviral therapy, and followed up every 26\u00a0weeks for 2\u00a0years. The association between LSM<\/jats:styled-content> and LRE<\/jats:styled-content>s was analysed by Cox proportional hazard model and Harrell C\u2010index analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 438 patients were included in the study. At the follow\u2010up of 104\u00a0weeks, LRE<\/jats:styled-content>s developed in 33\/438 (7.8%) patients, including 16 episodes of decompensation, 18 HCC<\/jats:styled-content> and 3 deaths. The median LSM<\/jats:styled-content> remained high from 20.9, 18.6, 20.4 to 20.3\u00a0Kpa at week 0, 26, 52 and 78 among patients with LRE<\/jats:styled-content>s, whereas the LSM<\/jats:styled-content> decreased from 17.8, 12.3, 10.6 to 10.2\u00a0Kpa in patients without LRE<\/jats:styled-content>s respectively. Percentage changes of LSM<\/jats:styled-content> at 26\u00a0weeks from baseline were significantly associated with LRE<\/jats:styled-content>s (excluding 11 cases occurred within the first 26\u00a0weeks), with a crude hazard ratio of 2.94 (95% CI<\/jats:styled-content>: 1.73\u20105.00) and an albumin\u2010adjusted hazard ratio of 2.47 (95% CI<\/jats:styled-content>: 1.49\u20104.11). The Harrell C\u2010index of these 2 models for predicting 2\u2010year LRE<\/jats:styled-content>s were 0.68 (95% CI<\/jats:styled-content>: 0.56\u20100.80) and 0.75 (95% CI<\/jats:styled-content>: 0.65\u20100.85) respectively. Nomograms were developed to identify individuals at high risk for point\u2010of\u2010care application.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Dynamic changes of LSM<\/jats:styled-content> alone, or combined with baseline albumin, could predict LRE<\/jats:styled-content>s in patients with HBV<\/jats:styled-content>\u2010related compensated cirrhosis during antiviral therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13623","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T01:36:34Z","timestamp":1510191394000},"page":"1045-1054","source":"Crossref","is-referenced-by-count":35,"title":["On\u2010treatment changes of liver stiffness at week 26 could predict 2\u2010year clinical outcomes in HBV<\/scp>\u2010related compensated cirrhosis"],"prefix":"10.1111","volume":"38","author":[{"given":"Shanshan","family":"Wu","sequence":"first","affiliation":[{"name":"Liver Research Center Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center of Digestive Diseases Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Kong","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center of Digestive Diseases Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxin","family":"Piao","sequence":"additional","affiliation":[{"name":"Infectious Department Affiliated Hospital of Yanbian University Yanji China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongshan Hospital Fudan University Shanghai 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