{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:55:39Z","timestamp":1771008939124,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The introduction of direct\u2010acting antivirals (DAA<\/jats:styled-content>) has increased sustained virological response (SVR<\/jats:styled-content>) rates in patients with advanced liver disease and chronic hepatitis C(CHC<\/jats:styled-content>)infection. At present, data on clinical outcome and long\u2010term durability of viral eradication after successful DAA<\/jats:styled-content> therapy are scarce.<\/jats:p><\/jats:sec>Aim<\/jats:title>To evaluate the long\u2010term success of viral eradication in patients with advanced fibrosis or cirrhosis treated with DAA<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Methods<\/jats:title>Five hundred and fifty\u2010one patients with advanced fibrosis (n\u00a0=\u00a0158) or cirrhosis (CPS<\/jats:styled-content>\u2010A:317,CPS<\/jats:styled-content>\u2010B\/C:76) and SVR<\/jats:styled-content> after interferon and ribavirin\u2010free DAA<\/jats:styled-content> therapy treated between October 2013 and April 2016 were studied with a median follow\u2010up of 65.6 (13.0\u2010155.3) weeks. Only patients without hepatocellular carcinoma (HCC<\/jats:styled-content>) at baseline and without liver transplantation were included.<\/jats:p><\/jats:sec>Results<\/jats:title>Twelve patients (2.2%) died during follow\u2010up: the mortality rate was 0.6% in F3, 2.2% in CPS<\/jats:styled-content>\u2010A and 5.3% in CPS<\/jats:styled-content>\u2010B\/C patients (P<\/jats:italic>\u00a0=\u00a0.08). During follow\u2010up 36 patients with cirrhosis (9.1%) developed a liver related event, including 16 with de\u2010novo HCC<\/jats:styled-content> (4.1%). Seven patients were transplanted at a median of 9.7 (range 3.8\u201021.7) months after EOT<\/jats:styled-content>. History of decompensation was significantly associated with liver related events during follow\u2010up (HR<\/jats:styled-content> 7.9; 95% CI<\/jats:styled-content> 2.7\u201022.6; P<\/jats:italic>\u00a0<\u00a0.001), and with mortality (HR<\/jats:styled-content> 5.5; 95% CI<\/jats:styled-content> 1.5\u201020.2, P<\/jats:italic>\u00a0=\u00a0.01).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Eradication of HCV<\/jats:styled-content> by DAA<\/jats:styled-content> therapy was durable irrespective of the DAA<\/jats:styled-content> combination used. Most of the cured patients had an excellent long\u2010term clinical prognosis. Nevertheless, the risk of new occurrence of HCC<\/jats:styled-content> remains worrisome and thus regular surveillance is obligatory even after clinical stabilization and improvement of the patient.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13629","type":"journal-article","created":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T16:22:39Z","timestamp":1510676559000},"page":"1028-1035","source":"Crossref","is-referenced-by-count":49,"title":["Follow\u2010up of sustained virological responders with hepatitis C and advanced liver disease after interferon\/ribavirin\u2010free treatment"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5012-7662","authenticated-orcid":false,"given":"Karin","family":"Kozbial","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna Vienna 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