{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:27:02Z","timestamp":1790263622993,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T00:00:00Z","timestamp":1513296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>The impact of nonalcoholic fatty liver disease (NAFLD<\/jats:styled-content>) on the natural history of primary biliary cholangitis (PBC<\/jats:styled-content>) has yet to be described. The aim of this study was to document the activity, severity and progression of PBC<\/jats:styled-content> in patients with concomitant NAFLD<\/jats:styled-content> and compare the findings to those with PBC<\/jats:styled-content> alone.<\/jats:p><\/jats:sec>Methods<\/jats:title>Disease activity was assessed by serum liver enzyme levels; severity, by Fib\u20104 scores and percent of patients with APRI<\/jats:styled-content> >1.5; and progression, by changes in Fib\u20104 and prevalence of APRI<\/jats:styled-content> >1.5 during follow\u2010up.<\/jats:p><\/jats:sec>Results<\/jats:title>The study populations consisted of 168 PBC<\/jats:styled-content> alone and 68 PBC<\/jats:styled-content>\/NAFLD<\/jats:styled-content> patients. The mean ages and gender distributions of the two cohorts were similar. At presentation, PBC<\/jats:styled-content> alone patients had greater disease activity (higher serum ALP<\/jats:styled-content> and GGT<\/jats:styled-content> values, P<\/jats:italic>\u00a0=\u00a0.003 and 0.01, respectively) and advanced disease (higher Fib\u20104 (P<\/jats:italic>\u00a0=\u00a0.04) scores) than PBC<\/jats:styled-content>\/NAFLD<\/jats:styled-content> patients. Although the prevalence of APRI<\/jats:styled-content> >1.5 was also higher in PBC<\/jats:styled-content> alone (11.1%) vs PBC<\/jats:styled-content>\/NAFLD<\/jats:styled-content> (4.7%) patients, the difference was not significant (P<\/jats:italic>\u00a0=\u00a0.16). During mean follow\u2010up of 6.7\u00a0\u00b1\u00a05.5 (PBC<\/jats:styled-content> alone) and 6.4\u00a0\u00b1\u00a04.4 (PBC<\/jats:styled-content>\/NAFLD<\/jats:styled-content>) years (ranges: 0.5\u201021\u00a0years) annual increases in Fib\u20104 and prevalence of \u2265 APRI<\/jats:styled-content> 1.5 were greater in PBC<\/jats:styled-content> alone patients but the differences did not reach statistical significance.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The results of this retrospective, single centre study suggest that the activity, severity and progression of PBC<\/jats:styled-content> are not adversely affected by concomitant NAFLD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13644","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T18:00:01Z","timestamp":1511978401000},"page":"1110-1116","source":"Crossref","is-referenced-by-count":23,"title":["Concomitant nonalcoholic fatty liver disease does not alter the activity, severity or course of primary biliary cholangitis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2687-940X","authenticated-orcid":false,"given":"Gerald Y.","family":"Minuk","sequence":"first","affiliation":[{"name":"Section of Hepatology Department of Internal Medicine Rady College of Medicine University of Manitoba Winnipeg MB Canada"},{"name":"Department of Pharmacology and Therapeutics Rady College of Medicine University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venera","family":"Iliant","sequence":"additional","affiliation":[{"name":"Section of Hepatology Department of Internal Medicine Rady College of Medicine University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Zhou","sequence":"additional","affiliation":[{"name":"Section of Hepatology Department of Internal Medicine Rady College of Medicine University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly D.","family":"Kaita","sequence":"additional","affiliation":[{"name":"Section of Hepatology Department of Internal Medicine Rady College of Medicine University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Wong","sequence":"additional","affiliation":[{"name":"Section of Hepatology Department of Internal Medicine Rady College of Medicine University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Peretz","sequence":"additional","affiliation":[{"name":"Section of Hepatology Department of Internal Medicine Rady College of Medicine University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Uhanova","sequence":"additional","affiliation":[{"name":"Section of Hepatology Department of Internal 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