{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T08:56:21Z","timestamp":1779008181251,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:00:00Z","timestamp":1515369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Among <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive individuals, seroprotection for hepatitis A virus (<jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content>) following primary vaccination may wane with time. However, seroresponses to <jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content> revaccination are rarely investigated among <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive patients who have lost protective antibodies after primary vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During the outbreak of acute hepatitis A in Taiwan after June 2015, <jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content>\u2010seronegative, <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive individuals were advised to receive two doses of <jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content> vaccines at 24\u00a0weeks apart. A retrospective 1:2 matched case\u2010control study was conducted to compare the seroresponses at weeks 4, 24, 28 and 48 of <jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content> vaccination between those who underwent revaccination after having lost protective antibodies (case patients) and those who underwent primary vaccination (controls).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010five case patients and 150 matched controls were included. The serological response rates were consistently higher among the case patients than controls: 88.1% vs 10.5% at week 4 following the first dose of <jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content> vaccination (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001); 93.3% vs 46.0% at week 24 (immediately before the second dose; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001); 98.7% vs 62.7% at week 28 (4\u00a0weeks after the second dose; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and 98.7% vs 92.7% at week 48 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.06). The anti\u2010<jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content> antibody titres as reflected by the semi\u2010quantitative assay for the case patients were also significantly higher than the controls at weeks 24, 28 and 48 following <jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content> vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We demonstrated faster and better serological responses to <jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content> revaccination among the <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive individuals who had lost their anti\u2010<jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content> antibodies after primary vaccination. Single dose of <jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content> revaccination may provide rapid and sufficient seroresponses for <jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content> during the outbreak of acute hepatitis A.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13665","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T19:12:46Z","timestamp":1513278766000},"page":"1198-1205","source":"Crossref","is-referenced-by-count":16,"title":["Serological responses to revaccination with hepatitis A virus (HAV) vaccines among <scp>HIV<\/scp>\u2010positive individuals whose anti\u2010HAV antibody waned after primary vaccination"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1310-4648","authenticated-orcid":false,"given":"Guan\u2010Jhou","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Yun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan\u2010Yin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine National Taiwan University Hospital Jin\u2010Shan Branch  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristine","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Chia","family":"Huang","sequence":"additional","affiliation":[{"name":"Department 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