{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:34:11Z","timestamp":1781822051376,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Genotype 1 chronic hepatitis C is associated with an impairment of glucose homoeostasis, especially in the advanced stages of the disease. Glucose tolerance is an independent predictor of liver\u2010related mortality in patients with cirrhosis because of chronic hepatitis C. However, no study has demonstrated so far weather hepatitis C virus clearance affects glucose tolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To this aim, we performed a prospective study assessing the effects of direct antiviral agents treatment in nondiabetic cirrhotic patients with genotypes 1a\/1b and impaired glucose tolerance based on a 75\u2010g oral glucose tolerance test. Impaired glucose tolerance was diagnosed by a 2\u2010hour plasma glucose between 140 and 199\u00a0mg\/dL. Insulin resistance was estimated by the oral glucose insulin sensitivity index, an oral glucose tolerance test\u2010derived measure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After meeting the inclusion criteria, the study population included 32 outpatients (26\/6 genotypes 1b\/1a; age 62\u00a0\u00b1\u00a07.4\u00a0years; 18 males) with compensated Child\u2010A cirrhosis. All patients achieved a sustained virological response following direct antiviral agents treatment. After viral eradication, we did not observe change in fasting plasma glucose (103.5\u00a0\u00b1\u00a07.1 vs 102.8\u00a0\u00b1\u00a07.2\u00a0mg\/dL, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.15) but 2\u2010hour plasma glucose was reduced (165.2\u00a0\u00b1\u00a022.7 vs 138.5\u00a0\u00b1\u00a021.3\u00a0mg\/dL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Hepatitis C virus eradication led also to a significant reduction in HbA1c (6.1\u00a0\u00b1\u00a00.2% vs 5.7\u00a0\u00b1\u00a00.3%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and post\u2010load insulin resistance as assessed by the oral glucose insulin sensitivity index (6.92\u00a0\u00b1\u00a01.56 vs 9.52\u00a0\u00b1\u00a01.39\u00a0mg\/kg\/min, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). These effects were observed despite no change in body mass index from baseline to follow\u2010up (25.6\u00a0\u00b1\u00a04.3 vs 25.8\u00a0\u00b1\u00a04.4, <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that hepatitis C virus eradication may early improve glucose tolerance in patients with hepatitis C virus\u2010related cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13669","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T16:12:11Z","timestamp":1513699931000},"page":"1206-1211","source":"Crossref","is-referenced-by-count":13,"title":["Hepatitis C virus eradication by direct antiviral agents improves glucose tolerance and reduces post\u2010load insulin resistance in nondiabetic patients with genotype 1"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5264-2935","authenticated-orcid":false,"given":"Federico","family":"Salomone","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Ospedale di Acireale Azienda Sanitaria Provinciale di Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Catania","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine Ospedale di Acireale Azienda Sanitaria Provinciale di Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Montineri","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Ospedale \u201cFerrarotto\u201d  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Bertino","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Godos","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Ultrasuoni Diagnostic Medical Center  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Magr\u00ec","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Ospedale di Acireale Azienda Sanitaria Provinciale di Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Li Volti","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences University of Catania  Catania 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