{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:00:14Z","timestamp":1740171614227,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>To describe the burden on inpatient hospital resources over time from patients diagnosed with hepatitis C virus (HCV) infection and who have reached the decompensated stage of cirrhosis (DC), as existing estimates of hospital stay in these patients are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective longitudinal dataset was formed via record\u2010linkage between the national HCV diagnosis database and inpatient\/daycase hospitalisation and death registers in Scotland. The study population consisted of HCV\u2010diagnosed patients with a first DC admission in 1996\u20102013, with follow\u2010up available until 31 May 2014. We investigated and quantified the mean cumulative length of hospital stay, distributions over discharge diagnosis categories, and trends in admission rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among our study population (n<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>1543), we identified 10\u00a0179 admissions with any diagnosis post\u2010first DC admission. Between 1996 and 2013 there was a 16\u2010fold rise in annual total admissions (from 112 to 1791) and an 11\u2010fold rise in hospital stay (719\u20108045). When restricting minimum possible follow\u2010up to 2\u00a0years, DC patients (n<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>1312) had an overall admission rate of 7.3 per person\u2010year, and spent on average 43\u00a0days (26\u00a0days during first 6\u00a0months) in hospital; for all liver\u2010related, liver\u2010related other than HCC\/DC, and non\u2010liver related only admissions, this was 39, 14, and 5\u00a0days respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HCV\u2010infected DC patients impose a considerable inpatient hospital burden, mostly from DC\u2010 and other liver\u2010related admissions, but also from admissions associated with non\u2010liver comorbidities. Estimates will be useful for monitoring the impact of prevention and treatment, and for computing the cost\u2010effectiveness of new therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13681","type":"journal-article","created":{"date-parts":[[2017,12,30]],"date-time":"2017-12-30T10:52:40Z","timestamp":1514631160000},"page":"1402-1410","source":"Crossref","is-referenced-by-count":8,"title":["Inpatient hospital burden of hepatitis C\u2010diagnosed patients with decompensated cirrhosis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0788-6011","authenticated-orcid":false,"given":"Scott A.","family":"McDonald","sequence":"first","affiliation":[{"name":"School of Health and Life Sciences Glasgow Caledonian University  Scotland UK"},{"name":"Health Protection Scotland  Glasgow Scotland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamish A.","family":"Innes","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Glasgow Caledonian University  Scotland UK"},{"name":"Health Protection Scotland  Glasgow Scotland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther J.","family":"Aspinall","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Glasgow Caledonian University  Scotland UK"},{"name":"Health Protection Scotland  Glasgow Scotland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Royal Infirmary of Edinburgh  Edinburgh Scotland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4130-1358","authenticated-orcid":false,"given":"Maryam","family":"Alavi","sequence":"additional","affiliation":[{"name":"Health Protection Scotland  Glasgow Scotland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Valerio","sequence":"additional","affiliation":[{"name":"School of 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