{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T21:11:57Z","timestamp":1794431517466,"version":"4.9.1"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,2,11]],"date-time":"2018-02-11T00:00:00Z","timestamp":1518307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8157040652"],"award-info":[{"award-number":["8157040652"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20150101"],"award-info":[{"award-number":["BK20150101"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Abstract<\/jats:title>Background and Aims<\/jats:title>Hematopoietic stem cell transplantation related hepatic vein occlusive disease (HSCT<\/jats:styled-content>\u2010HVOD<\/jats:styled-content>) has been researched extensively; however, little is known about the clinical features and treatment of pyrrolizidine alkaloid\u2010induced HVOD<\/jats:styled-content> (PA<\/jats:styled-content>\u2010HVOD<\/jats:styled-content>). This retrospective single centre study examined the clinical and laboratory characteristics of 108 patients with acute PA<\/jats:styled-content>\u2010HVOD<\/jats:styled-content> and explored the efficacy of anticoagulation and TIPS<\/jats:styled-content> therapy.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study included 108 consecutive patients with PA<\/jats:styled-content>\u2010HVOD<\/jats:styled-content> between July 2008 and June 2016. The clinical manifestations and the results of laboratory and imaging tests were evaluated. The survival rates of patients treated with different approaches were recorded.<\/jats:p><\/jats:sec>Results<\/jats:title>Serum total bilirubin was <34.2\u00a0\u03bcmol\/L (2\u00a0mg\/dL) in approximately 40% of patients. More than 90% of patients were presented with hepatomegaly, uneven liver perfusion in the balance phase, compressive stenosis of the hepatic segmental inferior vena cava and decreased peak velocity of portal vein blood flow. Severe portal hypertension was observed in all patients undergoing HVPG<\/jats:styled-content> examination or TIPS<\/jats:styled-content> operation. Anticoagulation therapy with low molecular weight heparin combined with warfarin was significantly more effective than liver protection and supportive therapy, and TIPS<\/jats:styled-content> further improved the prognosis of patients who did not respond to anticoagulation therapy. The total effective rate of the anticoagulation\u2010TIPS<\/jats:styled-content> ladder therapeutic strategy was 91%.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Patients with PA<\/jats:styled-content>\u2010HVOD<\/jats:styled-content> had different characteristics than those with HSCT<\/jats:styled-content>\u2010HVOD<\/jats:styled-content>. Anticoagulation and TIPS<\/jats:styled-content> treatment may be effective for patients with PA<\/jats:styled-content>\u2010HVOD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13684","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T11:55:45Z","timestamp":1514980545000},"page":"1867-1874","source":"Crossref","is-referenced-by-count":70,"title":["Clinical characteristics and treatment of pyrrolizidine alkaloid\u2010related hepatic vein occlusive disease"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0649-4457","authenticated-orcid":false,"given":"Yu Z.","family":"Zhuge","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Drum Tower Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Drum Tower Hospital 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Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Drum Tower Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Diagnosis Drum Tower Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiology Drum Tower Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Drum Tower Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao P.","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Drum Tower Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,11]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"15","article-title":"Sinusoidal obstruction syndrome (hepatic veno\u2010occlusive disease)","volume":"4","author":"Cathy Q","year":"2014","journal-title":"J Clin Exp 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