{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:59:14Z","timestamp":1764997154296,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T00:00:00Z","timestamp":1518220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Unsedated transnasal endoscopy may be used for detecting oesophageal varices. However, few studies evaluated feasibility and accuracy of this technique. We aimed to evaluate accuracy, interobserver agreement and safety of the transnasal ultrathin compared to conventional endoscopy in patients with cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included consecutive patients referred for screening or surveillance of oesophageal varices. Patients underwent unsedated transnasal and sedated conventional endoscopies at the same day, which were recorded in a digital video file and randomly analysed by two double\u2010blinded endoscopists. High\u2010risk varices were defined by the presence of large calibre or red wale marks. Accuracy, interobserver agreement and safety of transnasal were compared to conventional endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and thirty\u2010three cirrhotic patients (48% male, aged of 60\u00a0\u00b1\u00a05, 34% Child\u2010Pugh B\/C and 71% of cases for variceal screening) were included in the study. The prevalence of oesophageal varices and high\u2010risk oesophageal varices were 59% (n\u00a0=\u00a079) and 29% (n\u00a0=\u00a039) respectively. For the presence of oesophageal varices, transnasal GIE yielded sensitivity of 94% [95% Confidence Interval, CI 88\u201099], specificity of 89% [81\u201097] as well as positive and negative predictive value of 93% and 91% respectively. A satisfactory interobserver agreement was observed for the presence of oesophageal varices (\u03ba\u00a0=\u00a00.89) and high\u2010risk varices (\u03ba\u00a0=\u00a00.65). No serious adverse events were recorded; transnasal GIE was safe and significantly associated with lower rates of hypoxaemia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) and hypotension (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) compared to conventional endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Unsedated transnasal endoscopy was safe and had an excellent accuracy and high interobserver agreement for detecting oesophageal varices and for identifying high\u2010risk varices in cirrhotic patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13692","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T14:11:42Z","timestamp":1515679902000},"page":"1418-1426","source":"Crossref","is-referenced-by-count":11,"title":["Reliability and safety of transnasal compared to conventional endoscopy for detecting oesophageal varices in cirrhotic patients"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3670-9911","authenticated-orcid":false,"given":"Elio C.","family":"Castro Filho","sequence":"first","affiliation":[{"name":"Gastroenterology Department University of the State of Rio de Janeiro (UERJ)  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0931-6418","authenticated-orcid":false,"given":"Hugo","family":"Perazzo","sequence":"additional","affiliation":[{"name":"Laboratory of clinical research on STD\/AIDS Evandro Chagas National Institute of Infectious Disease (INI) \u2010 Oswaldo Cruz Foundation (FIOCRUZ)  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel A. P.","family":"Guimaraes","sequence":"additional","affiliation":[{"name":"Gastroenterology Department University of the State of Rio de Janeiro (UERJ)  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian","family":"Machado","sequence":"additional","affiliation":[{"name":"Gastroenterology Department University of the State of Rio de Janeiro (UERJ)  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia F.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Bonsucesso Federal Hospital  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata M.","family":"Perez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department University of the State of Rio de Janeiro (UERJ)  Rio de Janeiro Brazil"},{"name":"Internal Medicine Department Federal University of Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"},{"name":"D'Or Institute for Research and Education (IDOR)  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.01.021"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0901512"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328356ae49"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(94)70068-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-122008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9624"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05906.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07374.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1256474"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-966351"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21907"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2014.02.013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i2.345"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v6.i4.128"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.11.019"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13152"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840220145"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-921037"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12866"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1291483"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-41513"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.01.021"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.09.029"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.09.025"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-012-2367-4"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.01.029"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.13692","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.13692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T16:27:03Z","timestamp":1694276823000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.13692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,10]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/liv.13692"],"URL":"https:\/\/doi.org\/10.1111\/liv.13692","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"type":"print","value":"1478-3223"},{"type":"electronic","value":"1478-3231"}],"subject":[],"published":{"date-parts":[[2018,2,10]]}}}