{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:48:23Z","timestamp":1780325303142,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Liver volume (\n LV<\/jats:styled-content>\n ) can be non\u2010invasively determined from the analysis of computed tomography (\n CT<\/jats:styled-content>\n ) images, and in patients with acute liver injury (\n ALI<\/jats:styled-content>\n ) or failure (\n ALF<\/jats:styled-content>\n ), it can reflect the balance of structural collapse with hepatic regeneration. We examined its relation to cause of liver injury, measures of liver function and histopathological findings, and utility in prediction of complications and mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Two hundred and seventy\u2010three patients with\n ALF<\/jats:styled-content>\n \/\n ALI<\/jats:styled-content>\n admitted to a specialist intensive care unit were studied. One hundred and ninety\u2010nine patients (73%) had non\u2010acetaminophen (\n NA<\/jats:styled-content>\n ) aetiologies and 74 (27%) had acetaminophen\u2010induced disease.\n LV<\/jats:styled-content>\n and proportion of predicted\n LV<\/jats:styled-content>\n (\n PLV<\/jats:styled-content>\n %) were determined from admission\n CT<\/jats:styled-content>\n imaging.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n LV<\/jats:styled-content>\n and\n PLV<\/jats:styled-content>\n % showed marked variation when aetiologic groups were compared (\n P<\/jats:italic>\n \u00a0<\u00a0.0001), including loss in cases with indeterminate cause (\n LV<\/jats:styled-content>\n 939\u00a0cm\n 3<\/jats:sup>\n [\n IQR<\/jats:styled-content>\n 680\u20101259],\n PLV<\/jats:styled-content>\n % 56% [42\u201084]) and increase in Budd\u2010Chiari syndrome (1891\u00a0cm\n 3<\/jats:sup>\n [1601\u20102094], 121% [111\u2010131]). Progression to high\u2010grade encephalopathy was more common with smaller\n LV<\/jats:styled-content>\n and\n PLV<\/jats:styled-content>\n . A\u00a0<\u00a01000\u00a0cm\n 3<\/jats:sup>\n threshold identified\n NA<\/jats:styled-content>\n patients who later developed it with 93% (95%\n CI<\/jats:styled-content>\n 83\u201098) specificity and odds ratio 10.6 (3.3\u201034.5) at median 5\u00a0days prior to onset, and risk of death in those with\n NA<\/jats:styled-content>\n \u2010drug\u2010induced (\n DILI<\/jats:styled-content>\n ) or indeterminate disease with 91% (71\u201099) specificity and 63% (50\u201075) sensitivity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In patients with\n ALF<\/jats:styled-content>\n \/\n ALI<\/jats:styled-content>\n ,\n LV<\/jats:styled-content>\n shows marked variation by the cause of disease, and in prognostic importance. In indeterminate and\n DILI<\/jats:styled-content>\n cases, loss of volume to <1000\u00a0cm\n 3<\/jats:sup>\n may indicate irreversible liver injury and regenerative failure and serve as an early clinical predictor for the development of high\u2010grade encephalopathy and death.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.13725","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T14:48:59Z","timestamp":1519224539000},"page":"1592-1601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Clinical and prognostic associations of liver volume determined by computed tomography in acute liver failure"],"prefix":"10.1111","volume":"38","author":[{"given":"Abigail","family":"Zabron","sequence":"first","affiliation":[{"name":"Liver Intensive Therapy Unit Institute of Liver Studies Kings College Hospital London 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UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Heneghan","sequence":"additional","affiliation":[{"name":"Hepatology Institute of Liver Studies Kings College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Willars","sequence":"additional","affiliation":[{"name":"Liver Intensive Therapy Unit Institute of Liver Studies Kings College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Auzinger","sequence":"additional","affiliation":[{"name":"Liver Intensive Therapy Unit Institute of Liver Studies Kings College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Heaton","sequence":"additional","affiliation":[{"name":"Liver Transplant Surgery Institute of Liver Studies Kings College Hospital London 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