{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:35:09Z","timestamp":1780558509084,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>The Baveno VI and the expanded Baveno VI criteria were proposed to help identify patients who could safely avoid screening endoscopies for clinically significant varices among patients with compensated advanced chronic liver disease. However, these criteria require cross\u2010validation, especially in Asian populations where the aetiologies of liver disease are different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1035 patients, including 282 patients with compensated advanced chronic liver disease of different aetiology, were analysed. The compensated advanced chronic liver disease was defined by liver stiffness measurement \u226510\u00a0kPa, Child\u2010Pugh class A and absence of prior liver decompensation. High\u2010risk varix was defined as a grade \u22652 oesophageal varix, any varix with a red colour sign or gastric varices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High\u2010risk varixs were present in 19.5% (55\/282 patients) with compensated advanced chronic liver disease. Among compensated advanced chronic liver disease patients, the expanded criteria could spare more endoscopies (51.7%) than the original criteria (27.6%). However, the expanded criteria missed a greater number of high\u2010risk varixs (6.8%) than the original criteria (3.8%). When stratified according to liver disease aetiology, the negative predictive values for the original Baveno <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content> criteria were 0.92, 1.00, 1.00 and 1.00, and the negative predictive values for the expanded criteria were 0.92, 0.96, 0.92 and 0.93 for hepatitis B, hepatitis C, alcohol and non\u2010alcoholic fatty liver disease, respectively. High\u2010risk varixs were rarely detected in patients without compensated advanced chronic liver disease (1.1%, 8\/753 patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this Asian cohort study, the Baveno <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content> criteria were able to identify who could safely avoid screening endoscopy. The expanded Baveno <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content> criteria could spare more endoscopies but also could increase the odds of missing a high\u2010risk varix.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13732","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T19:30:44Z","timestamp":1519932644000},"page":"1442-1448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Validation of the Baveno VI and the expanded Baveno VI criteria to identify patients who could avoid screening endoscopy"],"prefix":"10.1111","volume":"38","author":[{"given":"Joohwan","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-5554","authenticated-orcid":false,"given":"Dong Hyun","family":"Sinn","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonseok","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geum\u2010Youn","family":"Gwak","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Seok","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Han","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Hyeok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Cheol","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Woon","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"72","volume-title":"Portal Hypertension. 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