{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:47:10Z","timestamp":1792021630171,"version":"4.4.0"},"reference-count":131,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AA020518"],"award-info":[{"award-number":["R01 AA020518"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK102142"],"award-info":[{"award-number":["R01 DK102142"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AA024733"],"award-info":[{"award-number":["U01 AA024733"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM103549"],"award-info":[{"award-number":["P20GM103549"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30GM118247"],"award-info":[{"award-number":["P30GM118247"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000867","name":"Commonwealth Scholarship Commission","doi-asserted-by":"publisher","award":["201708040024"],"award-info":[{"award-number":["201708040024"]}],"id":[{"id":"10.13039\/501100000867","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acetaminophen (<jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content>) overdose is the most frequent cause of acute liver failure in the USA and many other countries. Although the metabolism and pathogenesis of<jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content>has been extensively investigated for decades, the mechanisms by which<jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content>induces liver injury are incompletely known, which hampers the development of effective therapeutic approaches to tackle this important clinical problem. Autophagy is a highly conserved intracellular degradation pathway, which aims at recycling cellular components and damaged organelles in response to adverse environmental conditions and stresses as a survival mechanism. There is accumulating evidence indicating that autophagy is activated in response to<jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content>overdose in specific liver zone areas, and pharmacological activation of autophagy protects against<jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content>\u2010induced liver injury. Increasing evidence also suggests that hepatic autophagy is impaired in nonalcoholic fatty livers (<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>), and<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>patients are more susceptible to<jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content>\u2010induced liver injury. Here, we summarized the current progress on the role and mechanisms of autophagy in protecting against<jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content>\u2010induced liver injury.<\/jats:p>","DOI":"10.1111\/liv.13866","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T07:04:52Z","timestamp":1524467092000},"page":"1363-1374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":149,"title":["Role and mechanisms of autophagy in acetaminophen\u2010induced liver injury"],"prefix":"10.1111","volume":"38","author":[{"given":"Xiaojuan","family":"Chao","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutics University of Kansas Medical Center Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutics University of Kansas Medical Center Kansas City KS USA"},{"name":"Department of Toxicology School of Public Health Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-6980","authenticated-orcid":false,"given":"Hartmut","family":"Jaeschke","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutics University of Kansas Medical Center Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3167-5073","authenticated-orcid":false,"given":"Wen\u2010Xing","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutics University of Kansas Medical Center Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,14]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/15360288.2014.908993"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6904-12-11"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-007368"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1191"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2090"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.02.026"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2007.06.006"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-013-1007-6"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040482"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-00663-0_12"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.3727\/105221617X15084371374138"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)81731-8"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.09.022"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.129445"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28486"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.28.17940"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/67.2.322"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29265"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfs133"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0500-0"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59755"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio711"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28225"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26547"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28263"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172308"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.037"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.021"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.11.001"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3737"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27939"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2708"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5371"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5497.1717"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.12.004"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.6.15123"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.9.15291"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196371"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2152"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.7.15451"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2757"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.152.3.519"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.01.011"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M803180200"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/35056522"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.4.11863"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.12.011"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01370"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1740"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2009.09.011"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e09-08-0693"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.11.001"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.018648"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24690"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.08.005"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.05.033"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08680-w"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18017"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.025"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0606-z"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2012.14"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201008084"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq526"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07253.x"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.24633"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000298"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200910140"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911187107"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13392"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr048"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq419"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2012"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq430"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.018"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2017-0228"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.042"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14893"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.057"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.08.016"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.602284"},{"key":"e_1_2_15_82_1","first-page":"417A","article-title":"Double deletion of Pink1 and Parkin eliminates compensatory effects of a single deletion of Pink1 or Parkin on acetaminophen\u2010induced mitophagy and liver injury","author":"Wang H","year":"2017","journal-title":"Hepatology"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.413674"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.413682"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0069"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.03.026"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-20"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/59.1.169"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.10.185"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3301"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20150020"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200507002"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.04.043"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2021"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00248-10"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.118976"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.08.003"},{"key":"e_1_2_15_98_1","article-title":"Liver\u2010specific deficiency of unc\u201051 like kinase 1 and 2 protects mice from acetaminophen\u2010induced liver injury","author":"Sun Y","year":"2017","journal-title":"Hepatology"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.80"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.04.005"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0223"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2718"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12514"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22536"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22798"},{"key":"e_1_2_15_106_1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0022-5347(25)00230-7","article-title":"Obesity as a risk factor in drug\u2010induced organ injury: increased liver and kidney damage by acetaminophen in the obese overfed rat","volume":"241","author":"Corcoran GB","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_15_107_1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0022-3565(25)11045-8","article-title":"Phenobarbital induction and acetaminophen hepatotoxicity: resistance in the obese Zucker rodent","volume":"243","author":"Blouin RA","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.193813"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.09.002"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.08.015"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27216"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp235"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.11.016"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40124"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00352.2011"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21175"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.09.008"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2011.03.001"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.11.017"},{"key":"e_1_2_15_120_1","first-page":"305","article-title":"Acetaminophen\u2010induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome","volume":"119","author":"Imaeda AB","year":"2009","journal-title":"J Clin Invest"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2691"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.10.002"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3893"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101405"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07383"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2215"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1980"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.202911"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09663"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498254.2015.1026426"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24132"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2014.920823"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.13866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.13866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T21:11:54Z","timestamp":1751577114000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.13866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,14]]},"references-count":131,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/liv.13866"],"URL":"https:\/\/doi.org\/10.1111\/liv.13866","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,14]]},"assertion":[{"value":"2018-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}