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The definition of <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> in cirrhosis has been recently modified and the new diagnostic criteria are based on small changes in serum creatinine with respect to previous values, occurring within a short period of time. The use of this new definition may lead to an earlier identification of renal impairment and better prognostic stratification. Hepatorenal syndrome (<jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>) is a unique form of <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> developing in patients with end\u2010stage liver disease. Systemic circulatory dysfunction and marked kidney vasoconstriction play a key role in the development of <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>. The modification of the definition of <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> has also led to a change in the diagnostic criteria of <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>. The new diagnostic criteria are based on <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> stages and there is no need to reach a specific serum creatinine threshold. According to these new criteria, treatment with vasoconstrictors and albumin for the management of <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content> will be started at lower serum creatinine values, with expected higher response rates. Finally, there are consistent data showing that some urine biomarkers, particularly <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> (neutrophil gelatinase\u2010associated lipocalin), may be useful in daily clinical practice for the differential diagnosis of the cause of <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> in cirrhosis.<\/jats:p>","DOI":"10.1111\/liv.13893","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T07:39:49Z","timestamp":1527665989000},"page":"1891-1901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Hepatorenal syndrome in the era of acute kidney injury"],"prefix":"10.1111","volume":"38","author":[{"given":"Cristina","family":"Sol\u00e9","sequence":"first","affiliation":[{"name":"Liver Unit Hospital Clinic of Barcelona  Barcelona Catalonia Spain"},{"name":"Universitat de Barcelona  Barcelona Catalonia 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