{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:33Z","timestamp":1787015733444,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sigrid Juselius Foundation"},{"name":"State funding for University-level health research"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Abstract<\/jats:title>\n \n Background & Aims<\/jats:title>\n \n Endoscopic retrograde cholangiography (\n ERCP<\/jats:styled-content>\n ) has been considered the gold standard for the diagnosis and follow\u2010up of primary sclerosing cholangitis, but it has been replaced by less invasive magnetic resonance imaging and cholangiopancreatography (\n MRI<\/jats:styled-content>\n \u2010\n MRCP<\/jats:styled-content>\n ). However, the role of these two techniques in the evaluation of disease activity and severity needs to be elucidated.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients with primary sclerosing cholangitis (n: 48, male 31, median age: 35.7; 28.0\u201044.2) who underwent\n ERCP<\/jats:styled-content>\n and\n MRI<\/jats:styled-content>\n \u2010\n MRCP<\/jats:styled-content>\n within \u00b13\u00a0months for diagnosis or follow\u2010up, were reviewed.\n ERCP<\/jats:styled-content>\n and\n MRI<\/jats:styled-content>\n \u2010\n MRCP<\/jats:styled-content>\n images were scored using the modified Amsterdam score. Serum and biliary cytology markers of disease activity and severity were related to the imaging findings. Agreement on the assessment of the\n ERCP<\/jats:styled-content>\n \/\n MRCP<\/jats:styled-content>\n score was calculated by kappa\u2010statistics. Spearman\u2032s \u03c1 was calculated when appropriate.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The agreement between\n ERCP<\/jats:styled-content>\n and\n MRCP<\/jats:styled-content>\n in scoring bile duct changes for disease severity was only moderate (weighted kappa: 0.437; 95%\n CI<\/jats:styled-content>\n : 0.211\u20100.644 for intra\u2010 and 0.512; 95%\n CI<\/jats:styled-content>\n : 0.303\u20100.720 for extra\u2010hepatic bile ducts).\n ERCP<\/jats:styled-content>\n and\n MRCP<\/jats:styled-content>\n intra\u2010hepatic scores were associated to the surrogate marker alkaline phosphatase (\n P<\/jats:italic>\n \u00a0=\u00a0.02 for both). A weak correlation between\n MRCP<\/jats:styled-content>\n score for extra\u2010hepatic bile ducts and liver transplantation\/death was found (Spearman's \u03c1\u00a0=\u00a0.362, 95%\n CI<\/jats:styled-content>\n : 0.080\u20100.590,\n P<\/jats:italic>\n \u00a0=\u00a0.022). A weak correlation between intra\u2010 (Spearman\u2032s \u03c1\u00a0=\u00a0.322, 95%\n CI<\/jats:styled-content>\n : 0.048\u20100.551,\n P<\/jats:italic>\n \u00a0=\u00a0.022) and extra\u2010hepatic (Spearman`s \u03c1\u00a0=\u00a0.319, 95%\n CI<\/jats:styled-content>\n : 0.045\u20100.549,\n P<\/jats:italic>\n \u00a0=\u00a0.025) peribiliary enhancement on contrast\u2010enhanced\n MRI<\/jats:styled-content>\n and severity of biliary cytologic classification was found.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The overall agreement between\n ERCP<\/jats:styled-content>\n and\n MRI<\/jats:styled-content>\n \u2010\n MRCP<\/jats:styled-content>\n in assessing disease severity was moderate for intra\u2010 and extra\u2010hepatic bile ducts.\n MRI<\/jats:styled-content>\n \u2010\n MRCP<\/jats:styled-content>\n seems to have a minor role as surrogate marker of disease activity and progression in\n PSC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.13899","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T07:41:23Z","timestamp":1528962083000},"page":"2329-2339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The role of magnetic resonance imaging and endoscopic retrograde cholangiography in the evaluation of disease activity and severity in primary sclerosing cholangitis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9064-0612","authenticated-orcid":false,"given":"Andrea","family":"Tenca","sequence":"first","affiliation":[{"name":"Department of Medicine Clinic of Gastroenterology Helsinki University and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Mustonen","sequence":"additional","affiliation":[{"name":"Department of Surgery Helsinki University Helsinki 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