{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:37:04Z","timestamp":1790789824540,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>The quantification of lipopolysaccharide (LPS<\/jats:styled-content>) in biological fluids is challenging. We aimed to measure plasma LPS<\/jats:styled-content> concentration using a new method of direct quantification of 3\u2010hydroxymyristate (3\u2010HM<\/jats:styled-content>), a lipid component of LPS<\/jats:styled-content>, and to evaluate correlations between 3\u2010HM<\/jats:styled-content> and markers of liver function, endothelial activation, portal hypertension and enterocyte damage.<\/jats:p><\/jats:sec>Methods<\/jats:title>Plasma from 90 noninfected cirrhotic patients (30 Child\u2010Pugh [CP<\/jats:styled-content>]\u2010A, 30 CP<\/jats:styled-content>\u2010B, 30 CP<\/jats:styled-content>\u2010C) was prospectively collected. The concentration of 3\u2010HM<\/jats:styled-content> was determined by high\u2010performance liquid chromatography coupled with mass spectrometry.<\/jats:p><\/jats:sec>Results<\/jats:title>3\u2010HM<\/jats:styled-content> levels were higher in CP<\/jats:styled-content>\u2010C patients (CP<\/jats:styled-content>\u2010A\/CP<\/jats:styled-content>\u2010B\/CP<\/jats:styled-content>\u2010C: 68\/70\/103\u00a0ng\/mL, P<\/jats:italic>\u00a0=\u00a00.005). Patients with severe acute alcoholic hepatitis (n\u00a0=\u00a016; 113 vs 74\u00a0ng\/mL, P<\/jats:italic>\u00a0=\u00a00.012), diabetic patients (n\u00a0=\u00a022; 99 vs 70\u00a0ng\/mL, P<\/jats:italic>\u00a0=\u00a00.028) and those not receiving beta blockers (n\u00a0=\u00a044; 98 vs 72\u00a0ng\/mL, P<\/jats:italic>\u00a0=\u00a00.034) had higher levels of 3\u2010HM<\/jats:styled-content>. We observed a trend towards higher baseline levels of 3\u2010HM<\/jats:styled-content> in patients with hepatic encephalopathy (n\u00a0=\u00a07; 144 vs 76\u00a0ng\/mL, P<\/jats:italic>\u00a0=\u00a00.45) or SIRS<\/jats:styled-content> (n\u00a0=\u00a010; 106 vs 75\u00a0ng\/mL, P<\/jats:italic>\u00a0=\u00a00.114). In multivariate analysis, high levels of 3\u2010HM<\/jats:styled-content> were associated with CP<\/jats:styled-content> (OR<\/jats:styled-content>\u00a0=\u00a04.39; 95%CI<\/jats:styled-content>\u00a0=\u00a01.79\u201010.76) or MELD<\/jats:styled-content> (OR<\/jats:styled-content>\u00a0=\u00a08.24; 95%CI<\/jats:styled-content>\u00a0=\u00a03.19\u201021.32) scores. Patients dying from liver insufficiency (n\u00a0=\u00a06) during a 12\u2010month follow\u2010up had higher baseline levels of 3\u2010HM<\/jats:styled-content> (106 vs 75\u00a0ng\/mL, P<\/jats:italic>\u00a0=\u00a00.089).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In noninfected cirrhotic patients, 3\u2010HM<\/jats:styled-content> arises more frequently with impairment of liver function, heavy alcohol consumption, diabetic status, nonuse of beta blockers and a trend towards poorer outcome is also observed. The direct mass measurement of LPS<\/jats:styled-content> using 3\u2010HM<\/jats:styled-content> appears reliable to detect transient endotoxaemia and promising to manage the follow\u2010up of cirrhotic patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13916","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T08:36:18Z","timestamp":1529656578000},"page":"106-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Circulating levels of 3\u2010hydroxymyristate, a direct quantification of endotoxaemia in noninfected cirrhotic patients"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9648-813X","authenticated-orcid":false,"given":"Delphine","family":"Weil","sequence":"first","affiliation":[{"name":"Service d'H\u00e9patologie CHU Jean Minjoz Besan\u00e7on France"},{"name":"UPRES EA4266 Laboratoire Pathog\u00e8nes & Inflammation\/EPILAB Universit\u00e9 de Bourgogne Franche\u2010Comt\u00e9 Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul","family":"Pais de Barros","sequence":"additional","affiliation":[{"name":"INSERM LNC UMR 1231 Universit\u00e9 de Bourgogne Franche\u2010Comt\u00e9 Dijon France"},{"name":"LipSTIC LabEx Plateforme de BioMonitoring Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Mourey","sequence":"additional","affiliation":[{"name":"INSERM Etablissement Fran\u00e7ais du Sang Bourgogne Franche\u2010Comt\u00e9 UMR 1098 Interactions H\u00f4te\u2010Greffon\u2010Tumeur\/Ing\u00e9nierie Cellulaire et G\u00e9nique, LipSTIC LabEx, Plateforme de BioMonitoring Univ.Bourgogne Franche\u2010Comt\u00e9 Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Laheurte","sequence":"additional","affiliation":[{"name":"INSERM Etablissement Fran\u00e7ais du Sang Bourgogne Franche\u2010Comt\u00e9 UMR 1098 Interactions H\u00f4te\u2010Greffon\u2010Tumeur\/Ing\u00e9nierie Cellulaire et G\u00e9nique, LipSTIC LabEx, Plateforme de BioMonitoring Univ.Bourgogne Franche\u2010Comt\u00e9 Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Cypriani","sequence":"additional","affiliation":[{"name":"Service de Biochimie M\u00e9dicale CHU Jean Minjoz Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Badet","sequence":"additional","affiliation":[{"name":"Service de Radiologie CHU Jean Minjoz Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Delabrousse","sequence":"additional","affiliation":[{"name":"Service de Radiologie CHU Jean Minjoz Besan\u00e7on 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