{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:29:24Z","timestamp":1790022564942,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["No.F.10\u201001\/2007(SA\u2010I)"],"award-info":[{"award-number":["No.F.10\u201001\/2007(SA\u2010I)"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Pregnant women infected with HEV<\/jats:styled-content> develops adverse pregnancy outcomes like, abortions, intrauterine fetal death, still births, neonatal deaths, preterm delivery and maternal mortality.<\/jats:p><\/jats:sec>Aim<\/jats:title>To correlate oestrogen and its receptors ESR<\/jats:styled-content>1\u03b1 and ESR<\/jats:styled-content>2\u03b2 levels with HEV<\/jats:styled-content>\u2010associated feto\u2010maternal outcomes.<\/jats:p><\/jats:sec>Material & Methods<\/jats:title>A total of 142 pregnant women with HEV<\/jats:styled-content> infection and 142 pregnant controls were included in study from Department of Obstetrics & Gynaecology and Department of Medicine, Maulana Azad Medical College (MAMC<\/jats:styled-content>) and associated Lok Nayak Hospital (LNH<\/jats:styled-content>), New Delhi. Three millilitre of blood sample was collected in plain for quantification of oestrogen, and its receptors ESR<\/jats:styled-content>1\u03b1 and ESR<\/jats:styled-content>2\u03b2 using commercially available third\u2010generation ELISA<\/jats:styled-content> kits.<\/jats:p><\/jats:sec>Results<\/jats:title>The levels of oestrogen, ESR<\/jats:styled-content>1\u03b1 and ESR<\/jats:styled-content>2\u03b2 were considerably higher in HEV<\/jats:styled-content>\u2010infected pregnant women (20.11\u00a0\u00b1\u00a018.19\u00a0ng\/mL, 10.58\u00a0\u00b1\u00a03.27\u00a0ng\/mL, 10.42\u00a0\u00b1\u00a04.71\u00a0ng\/mL respectively) than pregnant controls (11.74\u00a0\u00b1\u00a06.42\u00a0ng\/mL, 9.11\u00a0\u00b1\u00a01.63\u00a0ng\/mL, 9.01\u00a0\u00b1\u00a01.18\u00a0ng\/mL respectively)(P<\/jats:italic>\u00a0<\u00a00.0001). It was found that oestrogen levels were significantly higher in pregnant women infected with HEV<\/jats:styled-content> who had preterm delivery, low birth weight babies and fetal loss (19.64\u00a0\u00b1\u00a017.60\u00a0ng\/mL, 19.71\u00a0\u00b1\u00a017.63\u00a0ng\/mL, 33.62\u00a0\u00b1\u00a023.20\u00a0ng\/mL respectively) than who had full term delivery, average birth weight babies and live babies (11.71\u00a0\u00b1\u00a08.77\u00a0ng\/mL, 11.99\u00a0\u00b1\u00a09.44\u00a0ng\/mL, 16.58\u00a0\u00b1\u00a014.98\u00a0ng\/mL respectively)(P<\/jats:italic>\u00a0<\u00a00.05). A significant negative correlation was observed between baby birth weight and oestrogen levels in HEV<\/jats:styled-content>\u2010infected pregnant women.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The high level of oestrogen plays an important role in preterm delivery, low birth weight babies and fetal mortality in pregnant women with HEV<\/jats:styled-content> infection through placental dysfunction. Moreover, oestrogen level is a significant predictor for preterm delivery and maternal mortality and ESR<\/jats:styled-content>2\u03b2 levels is a significant predictor for maternal mortality in pregnant women infected with HEV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13928","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T16:43:27Z","timestamp":1530895407000},"page":"633-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Role of oestrogen and its receptors in HEV<\/scp>\u2010associated feto\u2010maternal outcomes"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4129-6210","authenticated-orcid":false,"given":"Swati","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Medicine Maulana Azad Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mradul K.","family":"Daga","sequence":"additional","affiliation":[{"name":"Department of Medicine Maulana Azad Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology Maulana Azad Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed A.","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Biosciences Jamia Millia Islamia New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premashis","family":"Kar","sequence":"additional","affiliation":[{"name":"Department of Medicine Maulana Azad Medical College New Delhi 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