{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:16:44Z","timestamp":1790140604577,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T00:00:00Z","timestamp":1533859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Aim<\/jats:title><jats:p>In the era of direct\u2010acting antivirals (<jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>), active screening for hidden hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection is important for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> elimination. This study estimated the cost\u2010effectiveness and health\u2010related outcomes of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> screening and <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content> treatment of a targeted population in Korea, where anti\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> prevalence was 0.6% in 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A Markov model simulating the natural history of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection was used to examine the cost\u2010effectiveness of two strategies: no screening vs screening and <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content> treatment. Screening was performed by integration of the anti\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> test into the National Health Examination Program. From a healthcare system's perspective, the cost\u2010utility and the impact on <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related health events of one\u2010time anti\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> screening and <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content> treatment in Korean population aged 40\u201065\u00a0years was analysed with a lifetime horizon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> screening and <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content> treatment strategy increased quality\u2010adjusted life years (<jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>) by 0.0015 at a cost of $11.27 resulting in an incremental cost\u2010effectiveness ratio (<jats:styled-content style=\"fixed-case\">ICER<\/jats:styled-content>) of $7435 per <jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content> gained compared with no screening. The probability of the screening strategy to be cost\u2010effective was 98.8% at a willingness\u2010to\u2010pay of $27\u00a0205. Deterministic sensitivity analyses revealed the <jats:styled-content style=\"fixed-case\">ICER<\/jats:styled-content>s were from $4602 to $12\u00a0588 and sensitive to screening costs, discount rates and treatment acceptability. Moreover, it can prevent 32 <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related deaths, 19 hepatocellular carcinomas and 15 decompensated cirrhosis per 100\u00a0000 screened persons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A one\u2010time <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> screening and <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content> treatment of a Korean population aged 40\u201065\u00a0years would be highly cost\u2010effective, and significantly reduce the <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related morbidity and mortality compared with no screening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13930","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T05:55:13Z","timestamp":1531374913000},"page":"60-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cost\u2010effectiveness and health\u2010related outcomes of screening for hepatitis C in Korean population"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6128-6407","authenticated-orcid":false,"given":"Kyung\u2010Ah","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Inje University Ilsan Paik Hospital  Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8094-2433","authenticated-orcid":false,"given":"Wankyo","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Public Health Science Graduate School of Public Health Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8195-9250","authenticated-orcid":false,"given":"Hwa Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Cancer Control and Population Health Graduate School of Cancer Science and Policy National Cancer Center  Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8892-7104","authenticated-orcid":false,"given":"Moran","family":"Ki","sequence":"additional","affiliation":[{"name":"Department of Cancer Control and Population Health Graduate School of Cancer Science and Policy National Cancer Center  Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4274-2582","authenticated-orcid":false,"given":"Eun Sun","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-7990","authenticated-orcid":false,"given":"Sook\u2010Hyang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,10]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WHO.Global hepatitis report 2017.2017.http:\/\/apps.who.int\/iris\/bitstream\/10665\/255016\/1\/9789241565455-eng.pdf?ua=1. 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