{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:44:53Z","timestamp":1780494293805,"version":"3.54.1"},"reference-count":9,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T00:00:00Z","timestamp":1533859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aim<\/jats:title><jats:p>Obesity and metabolic syndrome are increasingly recognized as risk factors for hepatocellular adenomas (<jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content>). There is still sparse evidence whether weight loss or bariatric surgery could induce <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content> regression in these patients. In this brief report we describe the effect of weight loss on <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content> regression in severe obese patients that had undergone bariatric surgery in our centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed an Electronic Patient Database search and included all patients who underwent bariatric surgery in our bariatric referral centre and had an <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u201010 code of benign neoplasm of liver in our centre from (2006\u20102017). All imaging studies of eligible patients were re\u2010evaluated by the study radiologist. Primary outcome was change in maximal diameter of <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six of 11 eligible patients were excluded because their lesions were classified as probable focal nodular hyperplasia and two were lost to follow\u2010up. Finally, three women with solitary (n\u00a0=\u00a01) or multiple <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content> (n\u00a0=\u00a02) and a body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) ranging between 39 and 50\u00a0kg\/m<jats:sup>2<\/jats:sup> were included. In two patients, <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content> completely regressed in 1\u20102\u00a0years following bariatric surgery, after <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> reductions of 36%\u201048%. The third patient showed a reduction of &gt;50% in diameter of the largest <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content> in 2.5\u00a0years after bariatric surgery (31% <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> reduction), with complete resolution of smaller <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bariatric induced weight loss results in significant regression of <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content> in severe obese women, which emphasizes the role of overweight in <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content> pathophysiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13934","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T18:48:22Z","timestamp":1532026102000},"page":"2134-2136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Regression of hepatocellular adenoma after bariatric surgery in severe obese patients"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3070-8443","authenticated-orcid":false,"given":"Tom J. G.","family":"Gevers","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Rijnstate Hospital  Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. W.","family":"Marcel Spanier","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Rijnstate Hospital  Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Veendrick","sequence":"additional","affiliation":[{"name":"Department of Radiology Rijnstate Hospital  Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Maarten","family":"Vrolijk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Rijnstate Hospital  Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.05.023"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.222109"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12925"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02786.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22417"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04772.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.014"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10809"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2018.01.006"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.13934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.13934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T18:22:36Z","timestamp":1694802156000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.13934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,10]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/liv.13934"],"URL":"https:\/\/doi.org\/10.1111\/liv.13934","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,10]]},"assertion":[{"value":"2018-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}