{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:22:55Z","timestamp":1772252575719,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>Baveno VI<\/jats:styled-content> criteria enabled the screening of varices needing treatment (VNT<\/jats:styled-content>) without endoscopy but created confusion by not stating the method used to calculate the 5% missed VNT<\/jats:styled-content> limit, resulting in different calculations across validation studies. We analysed those calculations to clarify their diagnostic meaning.<\/jats:p><\/jats:sec>Methods<\/jats:title>(a) Literature review and recalculation of the missed VNT<\/jats:styled-content> rates according to the three definitions encountered. (b) Contingency table comparison of these latter to determine their diagnostic meanings. (c) Real case analysis. 4\/Simulation of variations in the three main statistical descriptors (VNT<\/jats:styled-content>, missed VNT<\/jats:styled-content> or spared endoscopies).<\/jats:p><\/jats:sec>Results<\/jats:title>Missed VNT<\/jats:styled-content> rates in the three definitions varied five\u2010 to 10\u2010fold across 7 papers. The contingency table showed that the definitions based on VNT<\/jats:styled-content> prevalence and spared endoscopy as reference corresponded, respectively, to sensitivity and negative predictive value (NPV<\/jats:styled-content>). The whole population\u2010based definition corresponded to diagnostic accuracy (not pertinent in that setting). Real case analysis showed that concerning liver stiffness, the 95% sensitivity and NPV<\/jats:styled-content> cut\u2010offs for VNT<\/jats:styled-content> were, respectively, 14.1 and 26.5 kP<\/jats:styled-content>a. The VNT<\/jats:styled-content>\u2010based definition offered a more statistically powerful paired comparison between diagnostic tests, whereas the definition based on spared endoscopies was hampered by an unpaired comparison. Case simulation showed that the VNT<\/jats:styled-content>\u2010based definition was the most sensitive to descriptor variations.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The definitions of missed VNT<\/jats:styled-content> rate placing VNT<\/jats:styled-content> or spared endoscopy as the denominator are appropriate, providing, respectively, sensitivity and NPV<\/jats:styled-content> for VNT<\/jats:styled-content>. We privilege the first since it corresponds to the true proportion of missed VNT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13945","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T15:49:06Z","timestamp":1534952946000},"page":"49-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["How to clarify the Baveno VI<\/scp> criteria for ruling out varices needing treatment by noninvasive tests"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4866-5274","authenticated-orcid":false,"given":"Paul","family":"Cal\u00e8s","sequence":"first","affiliation":[{"name":"Hepatology department University Hospital Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Buisson","sequence":"additional","affiliation":[{"name":"Hepatology department University Hospital Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-8585","authenticated-orcid":false,"given":"Federico","family":"Ravaioli","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Berger","sequence":"additional","affiliation":[{"name":"Hepatology department University Hospital Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlotta","family":"Carboni","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Marasco","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Festi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-23018-4_5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13732"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13497"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.04.023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29363"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13379"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2017.1374852"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.019"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.13945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.13945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T23:37:30Z","timestamp":1694821050000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.13945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,10]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/liv.13945"],"URL":"https:\/\/doi.org\/10.1111\/liv.13945","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,10]]},"assertion":[{"value":"2018-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}