{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:39:02Z","timestamp":1789141142496,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T00:00:00Z","timestamp":1541721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Royal Free Charity"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>De novo malignancies after liver transplantation represent one of the leading causes of death in the long\u2010term. It remains unclear whether liver transplant recipients have an increased risk of colorectal cancer and whether this negatively impacts on survival, particularly in those patients affected by primary sclerosing cholangitis and ulcerative colitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this national multicentre cohort retrospective study, the incidence of colorectal cancer in 8115 evaluable adult patients undergoing a liver transplantation between 1 January 1990 and 31 December 2010 was compared to the incidence in the general population through standardised incidence ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010two (0.6%) cases of colorectal cancer were identified at a median of 5.6\u00a0years postliver transplantation, predominantly grade 2 (76.9%) and stage T3 (50%) at diagnosis. The incidence rate of colorectal cancer in the whole liver transplant population was similar to the general <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> population (<jats:styled-content style=\"fixed-case\">SIR<\/jats:styled-content>: 0.92), but significantly higher (<jats:styled-content style=\"fixed-case\">SIR<\/jats:styled-content>: 7.0) in the group of patients affected by primary sclerosing cholangitis\/ulcerative colitis. One\u2010, five\u2010 and ten\u2010year survival rates from colorectal cancer diagnosis were 71%, 48% and 31%, respectively, and the majority of colorectal cancer patients died of cancer\u2010specific causes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liver transplantation alone is not associated with an increased risk of colorectal cancer development. The primary sclerosing cholangitis\/ulcerative colitis liver transplant population showed a significantly higher risk of colorectal cancer development than the general population, with a high proportion of advanced stage at diagnosis and a reduced patient survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13947","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T15:28:43Z","timestamp":1534951723000},"page":"353-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Incidence and outcome of colorectal cancer in liver transplant recipients: A national, multicentre analysis on 8115 patients"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-8013","authenticated-orcid":false,"given":"Gianluca","family":"Rompianesi","sequence":"first","affiliation":[{"name":"Sheila Sherlock Liver Unit UCL Institute for Liver and Digestive Health Royal Free 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