{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:10:42Z","timestamp":1771881042270,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:00:00Z","timestamp":1538438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Science, ICT & Future Planning","award":["2016R1A1A1A05005138"],"award-info":[{"award-number":["2016R1A1A1A05005138"]}]},{"DOI":"10.13039\/501100003669","name":"Research of Korea Centers for Disease Control and Prevention","doi-asserted-by":"crossref","award":["2016-ER5103-01"],"award-info":[{"award-number":["2016-ER5103-01"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>We compared the risk of hepatocellular carcinoma (HCC<\/jats:styled-content>) development between patients with chronic hepatitis B (CHB<\/jats:styled-content>) who achieved virological response (VR<\/jats:styled-content>; HBV<\/jats:styled-content>\u2010DNA<\/jats:styled-content>\u00a0<\u00a02000\u00a0IU\/mL) with nucleos(t)ide analogues (NUC<\/jats:styled-content>s) treatment (NUC<\/jats:styled-content>\u2010VR<\/jats:styled-content> group) and patients with inactive CHB<\/jats:styled-content> phase (ICHBP<\/jats:styled-content> group).<\/jats:p><\/jats:sec>Methods<\/jats:title>To adjust for imbalances between NUC<\/jats:styled-content>\u2010VR<\/jats:styled-content> and ICHBP<\/jats:styled-content> groups, propensity score matching (PSM<\/jats:styled-content>) models with 1:1 ratios were performed.<\/jats:p><\/jats:sec>Results<\/jats:title>This study included 2032 patients (n\u00a0=\u00a01291 in NUC<\/jats:styled-content>\u2010VR<\/jats:styled-content> group and n\u00a0=\u00a0741 in ICHBP<\/jats:styled-content> group). Before PSM<\/jats:styled-content>, NUC<\/jats:styled-content>\u2010VR<\/jats:styled-content> group was at higher risk of HCC<\/jats:styled-content> development than ICHBP<\/jats:styled-content> group at 7\u00a0years (9.4% in NUC<\/jats:styled-content>\u2010VR<\/jats:styled-content> group vs 3.3% in ICHBP<\/jats:styled-content> group; P<\/jats:italic>\u00a0<\u00a00.001). However, after PSM<\/jats:styled-content>, the cumulative HCC<\/jats:styled-content> development rates at 7\u00a0years were similar in NUC<\/jats:styled-content>\u2010VR<\/jats:styled-content> and ICHBP<\/jats:styled-content> groups using the three PSM<\/jats:styled-content> models [2.0% vs 4.3%, PSM<\/jats:styled-content> model\u20101 (612 pairs); 3.7% vs 4.4%, PSM<\/jats:styled-content> model\u20102 (618 pairs); and 2.4% vs 4.3%, PSM<\/jats:styled-content> model\u20103 (610 pairs)] (all P<\/jats:italic>\u00a0>\u00a00.05).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>After adjusting heavier hepatic fibrosis burden in NUC<\/jats:styled-content>\u2010VR<\/jats:styled-content> group, overall clinical outcomes between 2 groups had become comparable. Therefore, if appropriate, NUC<\/jats:styled-content>s to prevent viral replication and hepatic inflammation are required for achieving better prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13948","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T06:38:47Z","timestamp":1538548727000},"page":"81-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fibrosis\u2010matched outcomes between chronic hepatitis B patients with drug\u2010induced virological response and inactive carriers"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9690-9803","authenticated-orcid":false,"given":"Hye Soo","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oidov","family":"Baatarkhuu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Department of Infectious Diseases Mongolian National University of Medical Sciences Ulaanbaatar Mongolia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6324-2224","authenticated-orcid":false,"given":"Jun Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kijun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang\u2010Hyub","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beom Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9658-8050","authenticated-orcid":false,"given":"Seung Up","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.016"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.1.65"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033364"},{"issue":"67","key":"e_1_2_9_5_1","first-page":"370","article-title":"Clinical practice guidelines on the management of hepatitis B virus infection","volume":"2017","author":"EASL","year":"2017","journal-title":"J Hepatol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28552"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22841"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2016.22.1.18"},{"issue":"1647","key":"e_1_2_9_10_1","first-page":"e1646","article-title":"Association between level of fibrosis, rather than antiviral regimen, and outcomes of patients with chronic hepatitis B","volume":"14","author":"Kim HS","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802878"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051287"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24121"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306409"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2012.18.2.163"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3350\/kjhep.2012.18.1.1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i12.1890"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.061"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.02.033"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181a95c7f"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0522-7"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.02.026"},{"key":"e_1_2_9_24_1","first-page":"1109","article-title":"Virological suppression does not prevent the development of hepatocellular carcinoma in HBeAg\u2010negative chronic hepatitis B patients with cirrhosis receiving oral antiviral(s) starting with lamivudine monotherapy: results of the nationwide HEPNET","volume":"60","author":"Papatheodoridis GV","year":"2011","journal-title":"Greece cohort study. Gut"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28115"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036676"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2016.0069"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.13948","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.13948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T23:37:33Z","timestamp":1694821053000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.13948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,2]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/liv.13948"],"URL":"https:\/\/doi.org\/10.1111\/liv.13948","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,2]]},"assertion":[{"value":"2018-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}