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The aim of our study was to assess the efficacy and safety of the 8\u2010week administration of <jats:styled-content style=\"fixed-case\">PTV<\/jats:styled-content>\/r\/<jats:styled-content style=\"fixed-case\">OBV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DSV<\/jats:styled-content> in a real\u2010world cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a multicentre observational study from Spanish Hepa\u2010C database including patients receiving 8\u00a0weeks of <jats:styled-content style=\"fixed-case\">PTV<\/jats:styled-content>\/r\/<jats:styled-content style=\"fixed-case\">OBV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DSV<\/jats:styled-content> (October 2016\u2010November 2017). Those with advanced fibrosis, with non\u2010genotype 1b or who were treatment\u2010experienced were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 211 patients were registered from 23 Spanish centres; eleven were excluded. At baseline, 42.5% (n\u00a0=\u00a085) were male, median (range) age was 57 (23\u201086), <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> was 45 (11\u2010494)\u00a0IU\/mL, viral load was 6.1 (3.3\u20108.2) log10 IU\/mL, and 74.5% had mild liver fibrosis (F0\u2010F1) and 25.5% moderate fibrosis (F2). At the end of treatment (<jats:styled-content style=\"fixed-case\">EOT<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> viral load was undetectable in 100% (200\/200). Seven patients relapsed after treatment discontinuation. Sustained virological response (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>12) rates by intention\u2010to\u2010treat analysis were 96% (192\/200). Regarding treatment safety, 2 patients developed <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> elevation &gt;5x ULN, but there were no treatment discontinuations. One patient died 7\u00a0weeks after EOT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment with PTV\/r\/OBV\/DSV in genotype 1b\u2010infected treatment\u2010naive patients with mild\u2010moderate fibrosis shows excellent efficacy and safety in real life, similarly to clinical trials. Clinicaltrials.gov, number: <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>03122132.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13950","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T16:27:50Z","timestamp":1535646470000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Eight weeks of Paritaprevir\/r\/Ombitasvir + Dasabuvir in HCV genotype 1b with mild\u2010moderate fibrosis: Results from a real\u2010world cohort"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3694-3241","authenticated-orcid":false,"given":"Marc","family":"Puigveh\u00ed","sequence":"first","affiliation":[{"name":"Hospital del Mar, IMIM Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"De Cuenca","sequence":"additional","affiliation":[{"name":"Hospital 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