{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:25:29Z","timestamp":1762867529110,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T00:00:00Z","timestamp":1538179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Familial aggregation of metabolic traits in NAFLD is well documented. However, relevance of these traits in alcoholic cirrhosis is not well studied. We aimed to explore the association of family history of metabolic traits with age at diagnosis, severity and complications of alcoholic cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross\u2010sectional study, all consecutive patients with alcoholic cirrhosis presenting to our tertiary care centre were included. Family and personal history, demographic characteristics, medical history, anthropometric measurements and laboratory data were recorded. The amount and duration of alcohol consumption were also carefully recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 1084 alcoholic cirrhotics (age 48.5\u00a0\u00b1\u00a010.1\u00a0years, all males), family history for metabolic traits was documented in 688 (63.5%) patients. These patients had younger age at diagnosis, increased incidence of jaundice, ascites, variceal bleed and hepatic encephalopathy with consequently higher MELD and CTP score. These patients developed cirrhosis despite shorter median duration (13\u00a0years, IQR 7\u201020 vs 21, IQR 18\u201025) and lesser amount of alcohol consumption (74\u00a0g\/d, IQR 24\u201096 vs 144, IQR 100\u2010148). Patients with both family and personal history of metabolic traits had a higher risk by 3.3 times (95% CI 2.2\u20104.8) of an early age at diagnosis, 13.2 times (95% CI 8.7\u201020.1) of progression to cirrhosis with lesser amount of alcohol consumption and 4.6 times (95% CI 3.1\u20106.9) with lesser duration of alcohol consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Positive family and personal history of metabolic traits predispose to alcoholic cirrhosis with an earlier age at onset and more severity despite lesser exposure to alcohol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13958","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T12:42:06Z","timestamp":1536237726000},"page":"168-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Positive familial history for metabolic traits predisposes to early and more severe alcoholic cirrhosis: A cross\u2010sectional study"],"prefix":"10.1111","volume":"39","author":[{"given":"Ajeet Singh","family":"Bhadoria","sequence":"first","affiliation":[{"name":"Department of Clinical Research Institute of Liver and Biliary Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandan Kumar","family":"Kedarisetty","sequence":"additional","affiliation":[{"name":"Department of Hepatology Institute of Liver and Biliary Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chhagan","family":"Bihari","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Liver and Biliary Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guresh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Institute of Liver and Biliary Sciences New Delhi 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Clinical Nutrition Institute of Liver and Biliary Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3448-8334","authenticated-orcid":false,"given":"Manoj Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Hepatology Institute of Liver and Biliary Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0544-5610","authenticated-orcid":false,"given":"Shiv Kumar","family":"Sarin","sequence":"additional","affiliation":[{"name":"Department of Hepatology Institute of Liver and Biliary Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,29]]},"reference":[{"volume-title":"Alcohol and public health: alcohol related disease impact (ARDI)","year":"2012","author":"Center for Disease Control and 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