{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:10:33Z","timestamp":1785168633445,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>In patients with cirrhosis, the clinical benefit of the treatment with human albumin for ascites is debated, and no data are available regarding refractory ascites. In this study, in patients with cirrhosis and refractory ascites, we assessed the effect of long\u2010term albumin administration on emergent hospitalization and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy patients with cirrhosis and refractory ascites, followed at the Unit of Internal Medicine and Hepatology, University and General Hospital of Padova, Italy, were included into the study. Forty\u2010five patients were non\u2010randomly assigned to receive long\u2010term administration of human albumin at the doses of 20\u00a0g twice per week (n\u00a0=\u00a045), in addition to standard medical of care (SOC), and compared to those followed according to SOC. Patients were followed up to the end of the study, liver transplantation or death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cumulative incidence of 24\u2010month mortality was significantly lower in patients treated with albumin than in the group of patients treated with SOC (41.6% vs 65.5%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.032). The period free of emergent hospitalization was significantly longer in patients treated with long\u2010term administration of albumin (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.008). Analysing separately the causes of inpatient admission, patients treated with albumin showed a reduction in the incidence of overt hepatic encephalopathy, ascites, spontaneous bacterial peritonitis (SBP) and non\u2010SBP infections. In addition, a non\u2010significant trend towards a reduced probability of hepatorenal syndrome was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with cirrhosis and refractory ascites, long\u2010term treatment with albumin improves survival and reduces the probability of emergent hospitalizations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.13968","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T06:39:40Z","timestamp":1537339180000},"page":"98-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["Long\u2010term administration of human albumin improves survival in patients with cirrhosis and refractory ascites"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6996-3196","authenticated-orcid":false,"given":"Marco","family":"Di Pascoli","sequence":"first","affiliation":[{"name":"Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine\u2014DIMED University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvano","family":"Fasolato","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine\u2014DIMED University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Piano","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine\u2014DIMED University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bolognesi","sequence":"additional","affiliation":[{"name":"Unit of 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