{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T03:16:54Z","timestamp":1764645414883,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K15357"],"award-info":[{"award-number":["JP16K15357"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>It remains controversial whether the eradication of hepatitis C virus (HCV) by interferon (IFN)\u2010free anti\u2010HCV therapy using direct\u2010acting antivirals (DAAs) suppresses or promotes hepatocellular carcinoma (HCC) development. We investigated the influence of HCV eradication by DAA therapy on HCC development, by observing changes of non\u2010hypervascular hypointense nodules (NHHNs) by gadolinium\u2010ethoxybenzyl\u2010diethylenetriamine pentaacetic acid\u2010enhanced magnetic resonance imaging (EOB\u2010MRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 401 patients treated with DAA therapy who did not have a history of HCC were enrolled in this prospective cohort study. All patients underwent EOB\u2010MRI prior to the start of DAA therapy and were followed up periodically after therapy. The progression of NHHNs detected at baseline to typical HCC, as indicated by hypervascularization and the incidence of newly emergent NHHNs, was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In comparison of patients who achieved sustained virologic response (SVR) with propensity score\u2010matched patients with persistent HCV infection, there was no difference in the incidence of hypervascularization of NHHNs to typical HCC among patients who had NHHNs at baseline. Among patients who did not have NHHNs at baseline, the incidence of the new emergence of NHHNs did not differ between study patients and propensity score\u2013matched patients with persistent HCV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>During a 2\u2010year observation period after SVR, the eradication of HCV by IFN\u2010free DAA therapy did not suppress or enhance HCC development. (UMIN000017020).<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13987","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T15:11:20Z","timestamp":1539357080000},"page":"448-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The impact of HCV eradication by direct\u2010acting antivirals on the transition of precancerous hepatic nodules to HCC: A prospective observational study"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-6168","authenticated-orcid":false,"given":"Hidenori","family":"Toyoda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Ogaki Municipal Hospital Ogaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kumada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ogaki Municipal Hospital Ogaki 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