{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:03:31Z","timestamp":1790463811617,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T00:00:00Z","timestamp":1543708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002999","name":"Ministerie van Volksgezondheid, Welzijn en Sport","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002999","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,3]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>HIV<\/jats:styled-content>\/hepatitis B virus (HBV<\/jats:styled-content>) coinfected subjects are thought to have faster progression to end\u2010stage liver disease (ESLD<\/jats:styled-content>) than HBV<\/jats:styled-content> mono\u2010infected subjects. We assessed whether this remains in the current cART<\/jats:styled-content>\u2010era.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data from subjects with follow\u2010up completion post\u20102003 were compared between HIV<\/jats:styled-content>\/HBV<\/jats:styled-content> coinfected subjects in the Dutch HIV<\/jats:styled-content> Monitoring database and HBV<\/jats:styled-content> mono\u2010infected subjects from two centres. The primary outcomes of composite ESLD<\/jats:styled-content> included portal hypertension, decompensated cirrhosis, hepatocellular carcinoma, liver transplantation and liver\u2010related mortality. Outcomes were analysed using time\u2010dependent cause\u2010specific Cox regression models adjusted for follow\u2010up time and relevant covariates. Subset\u2010analyses were done in subjects with follow\u2010up pre\u20102003.<\/jats:p><\/jats:sec>Results<\/jats:title>In the 1336 co\u2010 vs 742 mono\u2010infected subjects, coinfected subjects had no increased probability for ESLD<\/jats:styled-content> compared to mono\u2010infected subjects (cHR<\/jats:styled-content> 0.7 (95% CI<\/jats:styled-content> 0.4\u20101.1), but had increased probabilities for all\u2010cause (cHR<\/jats:styled-content> 7.4 [4.9\u201011.1]) and liver\u2010related mortality (cHR<\/jats:styled-content> 3.4 [1.6\u20107.5]). In the current combined cohort, treatment with tenofovir or entecavir was inversely associated with ESLD<\/jats:styled-content>, all\u2010cause and liver\u2010related mortality (cHR<\/jats:styled-content> 0.4 [95% CI<\/jats:styled-content> 0.3\u20100.7], cHR<\/jats:styled-content> 0.003 [0.001\u20100.01]), cHR<\/jats:styled-content> 0.007 [0.001\u20100.05]). Other predictors for ESLD<\/jats:styled-content> were older age, being of Sub\u2010Sahara African descent, increased alanine aminotransferase levels and hepatitis C virus coinfection. While the probability for all\u2010cause mortality was increased in coinfected subjects, this rate decreased compared to pre\u20102003 (HR<\/jats:styled-content> 40.2 (95% CI<\/jats:styled-content>: 8.7\u2010186.2).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>HIV<\/jats:styled-content>\/HBV<\/jats:styled-content> coinfected patients no longer seem to be at increased risk for progression to ESLD<\/jats:styled-content> compared to HBV<\/jats:styled-content> mono\u2010infected patients, likely due to widespread use of highly effective cART<\/jats:styled-content> with dual HBV<\/jats:styled-content> and HIV<\/jats:styled-content> activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14000","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T11:30:08Z","timestamp":1541763008000},"page":"470-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Liver decompensation in HIV<\/scp>\/Hepatitis B coinfection in the combination antiretroviral therapy era does not seem increased compared to hepatitis B mono\u2010infection"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4816-3530","authenticated-orcid":false,"given":"Faydra I.","family":"Lieveld","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Department of Gastroenterology and Hepatology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colette","family":"Smit","sequence":"additional","affiliation":[{"name":"Stichting HIV Monitoring Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases Rijnstate Hospital Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel J.","family":"van Erpecum","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard W. M.","family":"Spanier","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Rijnstate Hospital Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth H.","family":"Gisolf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases Rijnstate Hospital Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.","family":"Vrolijk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Rijnstate Hospital Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Siersema","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Department of Gastroenterology and Hepatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy I. 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